ReviewParkinsonism & related disorders2018
The evolving definition of essential tremor: What are we dealing with?
Review in Parkinsonism & related disorders, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
29 citing papers in PubMed, 3 syntheses or guidelines pooled it, 52 citations in OpenAlex.
- Abnormalities of intrinsic brain activity in essential tremor: A meta-analysis of resting-state functional imaging.Human brain mapping · 2021Pooled it
- The global prevalence of essential tremor, with emphasis on age and sex: A meta-analysis.Journal of global health · 2021Pooled it
- No reliable gray matter changes in essential tremor.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2019Pooled it
- Structural brain changes in the development of essential tremor: toward early diagnosis.Frontiers in aging neuroscience · 2026Article
- Neuroprotective effects of telmisartan in a harmaline-induced model of essential tremor: modulation of the renin-angiotensin system and inflammatory pathways.Frontiers in pharmacology · 2026Article
- Essential Tremor Severity Assessment Using Handwriting Analysis and Machine Learning.Sensors (Basel, Switzerland) · 2025Article
- The cerebellar involvement in essential tremor: the connecting roads.Arquivos de neuro-psiquiatria · 2025Review
- Protocol for a Phase 2 randomized controlled patient-assessor blinded study: efficacy and safety of combined cortical and cerebellar dual-target transcranial magnetic stimulation for the treatment of essential tremor.Frontiers in neurology · 2024Article
- Vestibular reflexes in essential tremor: abnormalities of ocular and cervical vestibular-evoked myogenic potentials are associated with the cerebellum and brainstem involvement.Journal of neural transmission (Vienna, Austria : 1996) · 2023Article
- Exploring the link between essential tremor and Parkinson's disease.NPJ Parkinson's disease · 2023Article
- Exploring the diagnostic markers of essential tremor: A study based on machine learning algorithms.Open life sciences · 2023Article
- New horizons in late-onset essential tremor: a pre-cognitive biomarker of dementia?Age and ageing · 2022Article
- Baseline Infection Burden and Cognitive Function in Elders with Essential Tremor.Tremor and other hyperkinetic movements (New York, N.Y.) · 2021Article
- Analysis of Fine Motor Skills in Essential Tremor: Combining Neuroimaging and Handwriting Biomarkers for Early Management.Frontiers in human neuroscience · 2021Article
- "ET Plus": Instability of the Diagnosis During Prospective Longitudinal Follow-up of Essential Tremor Cases.Frontiers in neurology · 2021Article
- Tremor Syndromes: An Updated Review.Frontiers in neurology · 2021Review
- Stimulation-Induced Side Effects of Deep Brain Stimulation in the Ventralis Intermedius and Posterior Subthalamic Area for Essential Tremor.Frontiers in neurology · 2021Article
- Essential Tremor Within the Broader Context of Other Forms of Cerebellar Degeneration.Cerebellum (London, England) · 2020Review
- Longitudinal follow-up with VIM thalamic deep brain stimulation for dystonic or essential tremor.Neurology · 2020Article
- Essential tremor-plus: a controversial new concept.The Lancet. Neurology · 2020Review
Corrections and comments
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Authors and funding
1 author at 1 institution in 1 country.
Funding
Abstract
backgroundAlthough essential tremor (ET) is commonly encountered in clinical practice, historically, there has been considerable disagreement as how to best define it, and now with a growing sense of its clinical complexity, how to best encapsulate it. Here, I draw attention to five issues of current uncertainty.
methodsA PubMed search conducted on June 19, 2017 crossed "essential tremor" with 9 second search terms (e.g., definition, diagnosis).
resultsThere are several major issues of clinical and diagnostic uncertainty. Underlying each issue is a larger question about the nature of the underlying pathophysiology of ET. Does age of onset of ET matter? How much dystonia is acceptable in ET? How much in the way of "cerebellar signs" are acceptable? Are non-motor features due to the underlying disease or merely secondary to the clinical features? Is ET a single disease entity or something else?
conclusionsWe are learning more about ET and, as a by-product of these efforts, are struggling with its definition. Further understanding the nature of the underlying disease pathogenesis as well as the role the cerebellum and cerebellar relays play in this process will likely provide important clues to enable us to bring order to areas of uncertainty.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.