ReviewParkinsonism & related disorders2018
Essential tremor then and now: How views of the most common tremor diathesis have changed over time.
Review in Parkinsonism & related disorders, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
14 citing papers in PubMed, 1 synthesis or guideline pooled it.
- No reliable gray matter changes in essential tremor.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2019Pooled it
- The cerebellar involvement in essential tremor: the connecting roads.Arquivos de neuro-psiquiatria · 2025Review
- Essential tremor is associated with reduced serum ceruloplasmin levels.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2024Article
- Transcranial low-intensity ultrasound stimulation for treating central nervous system disorders: A promising therapeutic application.Frontiers in neurology · 2023Review
- Article
- Tau Isoform Profile in Essential Tremor Diverges From Other Tauopathies.Journal of neuropathology and experimental neurology · 2021Article
- Temporal control of muscle synergies is linked with alpha-band neural drive.The Journal of physiology · 2021Article
- Essential tremor: Is the word "essential" really essential?Parkinsonism & related disorders · 2020Article
- Parkinson's Disease Exhibits Amplified Intermuscular Coherence During Dynamic Voluntary Action.Frontiers in neurology · 2020Article
- Do We Belittle Essential Tremor by Calling It a Syndrome Rather Than a Disease? Yes.Frontiers in neurology · 2020Article
- Optical Measurements during Asleep Deep Brain Stimulation Surgery along Vim-Zi Trajectories.Stereotactic and functional neurosurgery · 2020Article
- A review of basal ganglia circuits and physiology: Application to deep brain stimulation.Parkinsonism & related disorders · 2019Review
- Quantitative Assessment of Pathological Tau Burden in Essential Tremor: A Postmortem Study.Journal of neuropathology and experimental neurology · 2019Article
- Knowledge about Essential Tremor: A Study of Essential Tremor Families.Frontiers in neurology · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author.
Funding
Abstract
backgroundEssential tremor (ET) is the most prevalent tremor diathesis. In this "then" and "now" piece, I detail how views of this disorder have changed over time.
methodsA PubMed search was conducted on June 15, 2017. The term "essential tremor" was crossed in sequential order with 14 s search terms (e.g., genetics, clinical).
resultsThe traditional view of ET was that it was monosymptomatic. An emerging view of ET is as a more clinically-complex entity with a range of possible motor and non-motor features. Traditionally, ET was viewed as autosomal dominant with complete penetrance by age 65. Current thinking is that, in addition to monogenic forms of ET, the disease is likely to be complex, with incomplete penetrance into advanced age. While non-genetic factors were traditionally presumed to exist, epidemiological studies have explored several potential environmental toxicants. The traditional olivary model of ET posited the existence of a central oscillator; an alternative is the cerebellar degenerative model, which is now under consideration.
conclusionsFor ET, there is clearly a "then" and "now" when one assesses changes in our understanding of the disease with time. Indeed, concepts relating to the clinical features, disease etiology and pathogenesis have all changed substantially.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.