Evidence map›Paper›PMID 28747251›Full record

ReviewCell calcium2018

SERCA control of cell death and survival.

Elie R Chemaly, Luca Troncone, Djamel Lebeche

Open access · greenAbstract readReview
In one paragraph

Review in Cell calcium, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 123 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
123citing papers in PubMed, 1 pooled it
8.8field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

123 citing papers in PubMed, 1 synthesis or guideline pooled it, 233 citations in OpenAlex.

  1. Pooled it
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  7. Losartan treatment attenuates the cardiorenal alterations in a rat model of hemorrhagic insular stroke.Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2026
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  11. Frontiers in immunology · 2026
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63 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Elie R ChemalyDivision of Nephrology and Hypertension, Department of Medicine, Morsani College of Medicine, University of South Florida, Tampa, FL, USA.
Luca TronconeCardiovascular Research Institute, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
Djamel LebecheCardiovascular Research Institute, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, New York, USA; Diabetes, Obesity and Metabolism Institute, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, New York, USA; Graduate School of Biological Sciences, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, New York, USA. Electronic address: djamel.lebeche@mssm.edu.
Icahn School of Medicine at Mount Sinai · USUniversity of South Florida · US

Funding

Stable Isotope and Metabolomics CoreP60DK020541 · NIDDK · YESHIVA UNIVERSITY · PI PESSIN, JEFFREY E. · 1986 to 2014
$29.8M
Translational Research CoreP30DK020541 · NIDDK · ALBERT EINSTEIN COLLEGE OF MEDICINE, INC · PI STREAMSON C CHUA · 2015 to 2026
$27.7M
Targeting Diabetes With Novel SERCA Allosteric ActivatorsR01DK111417 · NIDDK · UNIVERSITY OF TENNESSEE HEALTH SCI CTR · PI LEBECHE, DJAMEL · 2018 to 2022
$2.3M
Genetic Analysis of microRNAs Function in Diabetic CardiomyopathyR01HL097357 · NHLBI · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI LEBECHE, DJAMEL · 2010 to 2014
$2.1M
Genes and miRNAs controlled by ORAI3 in cardiovascular remodelingR21AG050072 · NIA · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI LEBECHE, DJAMEL, TREBAK, MOHAMED · 2016 to 2017
$471k
Targeting Diabetes With Novel Small Molecule TherapeuticsR56DK100624 · NIDDK · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI LEBECHE, DJAMEL · 2015 to 2015
$170k
NHLBI NIH HHS R01 HL097357NIA NIH HHS R21 AG050072NIDDK NIH HHS P30 DK020541NIDDK NIH HHS P60 DK020541NIDDK NIH HHS R01 DK111417NIDDK NIH HHS R56 DK100624
6 · The paper itself

Abstract

Intracellular calcium (Ca

Indexed as

ApoptosisAnimalsCalcium SignalingCell SurvivalHumansNeoplasmsSarcoplasmic Reticulum Calcium-Transporting ATPasesSarcoplasmic Reticulum Calcium-Transporting ATPasesApoptosisCalciumCancerCardiovascular diseasesCell deathDiabetesER stressHepatostatosisSERCASERCA isoformsSERCA therapies

Identifiers

PMID28747251
PMCPMC5748262
OpenAlexW2734661377

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.