ArticleVirology journal2017
Rubella, herpes simplex virus type 2 and preeclampsia.
Article in Virology journal, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.
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Who cites it
10 citing papers in PubMed, 1 synthesis or guideline pooled it, 16 citations in OpenAlex.
- SARS-CoV-2 infection during pregnancy and risk of preeclampsia: a systematic review and meta-analysis.American journal of obstetrics and gynecology · 2022Pooled it
- Maternal and Umbilical Cord Blood Levels of Lead and Cadmium in Sudanese Women with Preeclampsia.Journal of clinical medicine · 2026Article
- Use of antiviral medications during pregnancy and the likelihood of preeclampsia in a population-based register study.Scientific reports · 2025Article
- Previous abortion and preeclampsia in Kigali, Rwanda: a case-control study.Frontiers in cardiovascular medicine · 2025Article
- Fetal cord plasma herpesviruses and preeclampsia: an observational cohort study.Scientific reports · 2024Observational
- Deep metagenomic characterization of the gut virome in pregnant women with preeclampsia.mSphere · 2024Article
- Association between previous spontaneous abortion and preeclampsia: a case-control study.BMC pregnancy and childbirth · 2022Article
- Association between breastfeeding and preeclampsia in parous women: a case -control study.International breastfeeding journal · 2021Article
- The COVID-19 Pandemic: an Appraisal of its Impact on Human Immunodeficiency Virus Infection and Pre-Eclampsia.Current hypertension reports · 2021Review
- Hepatitis B infection and preeclampsia among pregnant Sudanese women.Virology journal · 2018Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPreeclampsia is a major health problem. Although, the pathophysiology of preeclampsia is not fully understood, there are recent studies on association between infections and preeclampsia.
objectiveThe aim of the present study was to investigate the association between maternal seropositivity of rubella, Herpes simplex virus type 2 (HSV-2) and preeclampsia.
methodA case -controls study (90 women in each arm) was conducted at Saad Abualila Maternity Hospital, Khartoum, Sudan. The cases were women with preeclampsia and the controls were healthy pregnant women. Rubella and HSV-2 IgG antibodies were analysed in the maternal sera of all of the participants using ELISA.
resultsThere was no significant difference in the age, parity and gestational age between the two groups. Maternal serum IgG seropositivity for rubella (92.2% vs. 34.4%, P < 0.001) and HSV-2 (87.8% vs. 57.8%, P < 0.001) were significantly higher in preeclampsia than in the controls. There was no significant difference in the maternal serum IgM seropositivity for rubella (3.3% vs. 2.2%, P = 0.650) and HSV-2 (2.2% vs. 1.1%, P = 0.560). All the IgM seropositive cases were IgG seropositive too. In binary logistic regression women with rubella (OR = 4.93; 95% CI = 2.082-11.692, P < 0.001) and HSV-2 (OR = 5.54; 95% CI = 2.48-12.38, P < 0.001) IgG seropositivity were at higher risk for preeclampsia.
conclusionIn the current study rubella and HSV-2 IgG seropositivity is associated with preeclampsia. Preventive measure should be implemented.
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