ArticleBMC plant biology2017
New insights into the roles of cucumber TIR1 homologs and miR393 in regulating fruit/seed set development and leaf morphogenesis.
Article in BMC plant biology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed, 67 citations in OpenAlex.
- Decoding MicroRNA-Guided Antiviral Defense in Cucurbitaceae: Regulatory Networks, RNA Silencing Cross-Talk, and Emerging Strategies for Crop Resilience.International journal of molecular sciences · 2026Review
- Stu-miR393-5p-StTIR1A-StPLC2 module regulates the development of adventitious and lateral roots of potato.Plant cell reports · 2026Article
- Integrated genome-wide domestication and association analyses reveal the complex genetic basis of parthenocarpy during cucumber domestication.Molecular horticulture · 2026Article
- Uncovering seed vigor responsive miRNA in hybrid wheat and its parents by deep sequencing.BMC genomics · 2024Article
- Genome-Wide Analysis Elucidates the Roles ofPlants (Basel, Switzerland) · 2024Article
- Article
- New Advances in the Study of Regulation of Tomato Flowering-Related Genes Using Biotechnological Approaches.Plants (Basel, Switzerland) · 2024Review
- MicroRNAs associated with AGL6 and IAA9 function in tomato fruit set.BMC research notes · 2023Article
- Integrated Analysis of miRNAome and Transcriptome Identify Regulators of Elm Seed Aging.Plants (Basel, Switzerland) · 2023Article
- Morphological and Genetic Diversity of Cucumber (Plants (Basel, Switzerland) · 2022Review
- Molecular Mechanisms of Diverse Auxin Responses during Plant Growth and Development.International journal of molecular sciences · 2022Review
- Identification of miRNAs and Target Genes at Key Stages of Sexual Differentiation in AndrodioeciousInternational journal of molecular sciences · 2022Article
- The miR393-Target Module Regulates Plant Development and Responses to Biotic and Abiotic Stresses.International journal of molecular sciences · 2022Review
- Expression Profiles and Characteristics of Apple lncRNAs in Roots, Phloem, Leaves, Flowers, and Fruit.International journal of molecular sciences · 2022Article
- Inflammation in Coronary Atherosclerosis and Its Therapeutic Implications.Cardiovascular drugs and therapy · 2022Review
- Article
- Hormonal interactions underlying parthenocarpic fruit formation in horticultural crops.Horticulture research · 2022Article
- MicroRNAs Are Involved in Regulating Plant Development and Stress Response through Fine-Tuning of TIR1/AFB-Dependent Auxin Signaling.International journal of molecular sciences · 2022Review
- Article
- High-Throughput Sequencing and Expression Analysis Suggest the Involvement ofInternational journal of molecular sciences · 2020Article
Corrections and comments
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Authors and funding
11 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundTIR1-like proteins act as auxin receptors and play essential roles in auxin-mediated plant development processes. The number of auxin receptor family members varies among species. While the functions of auxin receptor genes have been widely studied in Arabidopsis, the distinct functions of cucumber (Cucumis sativus L.) auxin receptors remains poorly understood. To further our understanding of their potential role in cucumber development, two TIR1-like genes were identified and designated CsTIR1 and CsAFB2. In the present study, tomato (Sonanum lycopersicum) was used as a model to investigate the phenotypic and molecular changes associated with the overexpression of CsTIR1 and CsAFB2.
resultsDifferences in the subcellular localizations of CsTIR1 and CsAFB2 were identified and both genes were actively expressed in leaf, female flower and young fruit tissues of cucumber. Moreover, CsTIR1- and CsAFB2-overexpressing lines exhibited pleotropic phenotypes ranging from leaf abnormalities to seed germination and parthenocarpic fruit compared with the wild-type plants. To further elucidate the regulation of CsTIR1 and CsAFB2, the role of the miR393/TIR1 module in regulating cucumber fruit set were investigated. Activation of miR393-mediated mRNA cleavage of CsTIR1 and CsAFB2 was revealed by qPCR and semi-qPCR, which highlighted the critical role of the miR393/TIR1 module in mediating fruit set development in cucumber.
conclusionOur results provide new insights into the involvement of CsTIR1 and CsAFB2 in regulating various phenotype alterations, and suggest that post-transcriptional regulation of CsTIR1 and CsAFB2 mediated by miR393 is essential for cucumber fruit set initiation. Collectively, these results further clarify the roles of cucumber TIR1 homologs and miR393 in regulating fruit/seed set development and leaf morphogenesis.
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