ArticleBMC cardiovascular disorders2017
Acute coronary syndrome and acute kidney injury: role of inflammation in worsening renal function.
Article in BMC cardiovascular disorders, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.
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Who cites it
23 citing papers in PubMed, 1 synthesis or guideline pooled it, 37 citations in OpenAlex.
- Brain Natriuretic Peptide for Predicting Contrast-Induced Acute Kidney Injury in Patients with Acute Coronary Syndrome Undergoing Coronary Angiography: A Systematic Review and Meta-Analysis.Journal of interventional cardiology · 2020Pooled it
- Independent predictors of acute kidney injury in patients with acute coronary syndrome after percutaneous coronary intervention.PloS one · 2021Trial
- Acute coronary syndrome is associated with acute kidney injury on admission but not during hospital stay.Renal failure · 2026Article
- Emerging Prognostic Risk Factors in Acute Coronary Syndromes: Beyond Traditional Risk Assessment.Journal of clinical medicine · 2026Review
- Proenkephalin improves cardio-renal risk prediction in acute coronary syndromes: the KID-ACS score.European heart journal · 2025Article
- Assessment of the renal angina index in patients hospitalized in a cardiac intensive care unit.Scientific reports · 2024Article
- Neutrophil Percentage as a Potential Biomarker of Acute Kidney Injury Risk and Short-Term Prognosis in Patients with Acute Myocardial Infarction in the Elderly.Clinical interventions in aging · 2024Observational
- Association between dietary inflammatory index and chronic kidney disease in middle-aged and elderly populations.Frontiers in nutrition · 2024Article
- Worsening renal function in hospitalized patients with systolic heart failure: prevalence and risk factors.ESC heart failure · 2023Article
- Prognostic value of C-reactive protein to albumin ratio for mortality in acute kidney injury.BMC nephrology · 2023Article
- Cardiorenal syndrome: long road between kidney and heart.Heart failure reviews · 2022Review
- Cardiorenal syndrome: Pathophysiology as a key to the therapeutic approach in an under-diagnosed disease.Journal of clinical ultrasound : JCU · 2022Review
- Acute Kidney Injury After Open Heart Surgery.Cureus · 2022Article
- High uric acid level increases the risk of acute kidney injury in acute coronary syndrome patients.Caspian journal of internal medicine · 2021Article
- Association Between Serum Creatinine Concentrations and Overall Survival in Patients With Colorectal Cancer: A Multi-Center Cohort Study.Frontiers in oncology · 2021Article
- Deciphering key genes in cardio-renal syndrome using network analysis.Bioinformation · 2021Article
- The inflammasome NLRP3 plays a dual role on mouse corpora cavernosa relaxation.Scientific reports · 2019Article
- Wnt/β-catenin signaling mediates both heart and kidney injury in type 2 cardiorenal syndrome.Kidney international · 2019Article
- Predictors of acute kidney injury (AKI) in high-risk ST-elevation myocardial infarction (STEMI) patients: A single-center retrospective observational study.Bosnian journal of basic medical sciences · 2019Observational
- Combination of Amino-Terminal Pro- BNP , Estimated GFR , and High-Sensitivity CRP for Predicting Cardiorenal Syndrome Type 1 in Acute Myocardial Infarction Patients.Journal of the American Heart Association · 2018Observational
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAcute Kidney Injury (AKI), a common complication of acute coronary syndromes (ACS), is associated with higher mortality and longer hospital stays. The role of cytokines and other mediators is unknown in AKI induced by an ACS (ACS-AKI), leading to several unanswered questions. The worsening of renal function is usually seen as a dichotomous phenomenon instead of a dynamic change, so evaluating changes of the renal function in time may provide valuable information in the ACS-AKI setting. The aim of this study was to explore inflammatory factors associated to de novo kidney injury induced by de novo cardiac injury secondary to ACS.
methodsOne hundred four consecutive patients with ACS were initially included on the time of admission to the Coronary Unit of the Instituto Nacional de Cardiología in Mexico City, from February to May 2016, before any invasive procedure, imaging study, diuretic or anti-platelet therapy. White blood count, hemoglobin, NT-ProBNP, troponin I, C-reactive protein, albumin, glucose, Na
resultsPositive correlations of ΔCr were found with BUN, admission Cr, GRACE score, IL-1β, IL-6, NT-ProBNP and age, and negative correlations with systolic blood pressure, mean-BP, diastolic-BP and LxA4. In the regression analyses IL-10 and RvD1 had positive non-linear associations with ΔCr. ET-1 had also a positive association. Significant non-linear associations were seen with NT-proBNP, admission Cr, BUN, Na
conclusionInflammation and its components play an important role in the worsening of renal function in ACS. IL-10, ET-1, IL-1β, TnI, RvD1 and LxA4 represent mediators that might be associated with ACS-AKI. IL-6, ET-1, NT-ProBNP might represent crossroads for several physiopathological pathways involved in "de novo cardiac injury leading to de novo kidney injury".
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