ArticleActa radiologica (Stockholm, Sweden : 1987)2018
Body composition predictors of therapy response in patients with primary extremity soft tissue sarcomas.
Article in Acta radiologica (Stockholm, Sweden : 1987), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
12 citing papers in PubMed, 1 synthesis or guideline pooled it, 21 citations in OpenAlex.
- Adiposity and cancer survival: a systematic review and meta-analysis.Cancer causes & control : CCC · 2022Pooled it
- Computed tomography-based nutritional associated nomogram on machine learning predicts survival outcomes in patients with resectable soft-tissue sarcoma.World journal of radiology · 2026Article
- Body Composition Measurements as Predictive Variables for Outcomes of Canine Appendicular Osteosarcoma Treated With Stereotactic Body Radiation Therapy.Veterinary and comparative oncology · 2025Article
- Is visceral fat thickness related to outcomes in cancer patients with pulmonary embolism?Revista da Associacao Medica Brasileira (1992) · 2025Article
- Opportunistic CT for Prediction of Adverse Postoperative Events in Patients with Spinal Metastases.Diagnostics (Basel, Switzerland) · 2024Article
- Abdominal Fat Characteristics and Mortality in Rectal Cancer: A Retrospective Study.Nutrients · 2023Article
- Body composition predictors of mortality in patients undergoing surgery for long bone metastases.Journal of surgical oncology · 2022Article
- Body composition predictors of mortality on computed tomography in patients with spinal metastases undergoing surgical treatment.The spine journal : official journal of the North American Spine Society · 2022Article
- Body Composition Predictors of Adverse Postoperative Events in Patients Undergoing Surgery for Long Bone Metastases.Journal of the American Academy of Orthopaedic Surgeons. Global research & reviews · 2022Article
- Opportunistic muscle measurements on staging chest CT for extremity and truncal soft tissue sarcoma are associated with survival.Journal of surgical oncology · 2020Article
- Association of adipose tissue and skeletal muscle metrics with overall survival and postoperative complications in soft tissue sarcoma patients: an opportunistic study using computed tomography.Quantitative imaging in medicine and surgery · 2020Article
- CoreSlicer: a web toolkit for analytic morphomics.BMC medical imaging · 2019Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
Background Recent studies have suggested that the quantity and quality of adipose tissue and muscle, assessed on non-contrast computed tomography (CT), may serve as imaging biomarkers of survival in patients with and without neoplasms. Purpose To assess body composition measures that could serve as predictors of therapy response in patients with extremity soft tissue sarcomas treated with radiation therapy and surgery. Material and Methods The study was IRB-approved. Sixty patients had a history of extremity soft tissue sarcoma and underwent FDG-PET/CT prior to radiation therapy and surgical resection. Cross-sectional areas and CT attenuation (HU) of abdominal subcutaneous adipose tissue (SAT), visceral adipose tissue (VAT), and psoas muscle were assessed on non-contrast CT. Clinical information on predictors of tumor recurrence and post-surgical wound infections were recorded. Cox proportional hazard models were used to determine longitudinal associations between body composition and tumor recurrence/wound infections. Results Twenty-three tumor recurrences occurred over a follow-up period of 43 ± 35 months. Higher SAT and lower psoas attenuation were associated with tumor recurrence which remained significant after adjustment for covariates ( P ≤ 0.01). There were 13 post-surgical wound infections. Higher VAT and SAT attenuation were associated with post-surgical wound infections ( P < 0.04); however, VAT attenuation lost significance after adjustment for covariates. Conclusion Abdominal adipose tissue and psoas muscle attenuation assessed on non-contrast CT may predict tumor recurrence and post-surgical infections in patients with extremity soft tissue sarcomas.
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