ArticleBiophysical journal2017
A Versatile Framework for Simulating the Dynamic Mechanical Structure of Cytoskeletal Networks.
Article in Biophysical journal, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers.
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Who cites it
43 citing papers in PubMed, 95 citations in OpenAlex.
- Contractile to extensile transitions and mechanical adaptability enabled by activity in cytoskeletal structures.bioRxiv : the preprint server for biology · 2026Article
- Rapid actin filament turnover maintains cortical connectivity while allowing for cell cortex deformation and flow.bioRxiv : the preprint server for biology · 2026Article
- Viscoelasticity analysis of coarse-grained cytoskeletal simulations with Cytosim and Cytocalc.Biophysical journal · 2026Article
- Form and function in biological filaments: a physicist's review.Philosophical transactions. Series A, Mathematical, physical, and engineering sciences · 2025Review
- Engineering filamentous myosins for optical control of contractility.bioRxiv : the preprint server for biology · 2025Article
- Article
- Architecture mechanics mediated osteogenic progression in bone regeneration of artificial scaffolds.Science advances · 2025Article
- Polarity sorting of actin filaments by motor-driven cargo transport.Biophysical journal · 2025Article
- Emergence of diverse patterns driven by molecular motors in the motility assay.Cytoskeleton (Hoboken, N.J.) · 2024Article
- Morphometric analysis of actin networks.Molecular biology of the cell · 2024Article
- Growth-induced collective bending and kinetic trapping of cytoskeletal filaments.Cytoskeleton (Hoboken, N.J.) · 2024Article
- Discrete network models of endothelial cells and their interactions with the substrate.Biomechanics and modeling in mechanobiology · 2024Article
- Adaptive nonequilibrium design of actin-based metamaterials: Fundamental and practical limits of control.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Highly flexible PEG-LifeAct constructs act as tunable biomimetic actin crosslinkers.Soft matter · 2024Article
- Growth-induced collective bending and kinetic trapping of cytoskeletal filaments.bioRxiv : the preprint server for biology · 2024Article
- A unified model for the dynamics of ATP-independent ultrafast contraction.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- A coarse-grained simulation model for colloidal self-assemblySoft matter · 2023Article
- Myosin and [Formula: see text]-actinin regulation of stress fiber contractility under tensile stress.Scientific reports · 2023Article
- Organization and dynamics of cross-linked actin filaments in confined environments.Biophysical journal · 2023Article
- Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
Abstract
Computer simulations can aid in understanding how collective materials properties emerge from interactions between simple constituents. Here, we introduce a coarse-grained model that enables simulation of networks of actin filaments, myosin motors, and cross-linking proteins at biologically relevant time and length scales. We demonstrate that the model qualitatively and quantitatively captures a suite of trends observed experimentally, including the statistics of filament fluctuations, and mechanical responses to shear, motor motilities, and network rearrangements. We use the simulation to predict the viscoelastic scaling behavior of cross-linked actin networks, characterize the trajectories of actin in a myosin motility assay, and develop order parameters to measure contractility of a simulated actin network. The model can thus serve as a platform for interpretation and design of cytoskeletal materials experiments, as well as for further development of simulations incorporating active elements.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.