ArticleAngewandte Chemie (International ed. in English)2017
Enantioselective Tandem Cyclization of Alkyne-Tethered Indoles Using Cooperative Silver(I)/Chiral Phosphoric Acid Catalysis.
Article in Angewandte Chemie (International ed. in English), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed, 55 citations in OpenAlex.
- Catalytic asymmetric synthesis of (N, N)- spiroketal via Pd-catalyzed enantioconvergent aminocarbonylation and dearomative nucleophilic aza-addition.Nature communications · 2025Article
- Diversity-Oriented Catalytic Asymmetric Dearomatization of Indoles with o-Quinone Diimides.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2023Article
- Hydrogen Bond Assisted Three-Component Tandem Reactions to AccessMolecules (Basel, Switzerland) · 2023Article
- Modular Synthesis of Polycyclic Alkaloid Scaffolds via an Enantioselective Dearomative Cascade.Organic letters · 2020Article
- Tryptoline-based benzothiazoles re-sensitize MRSA to β-lactam antibiotics.Bioorganic & medicinal chemistry · 2019Article
- Zn(OTf)Chemical science · 2019Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
Reported is the enantioselective synthesis of tetracyclic indolines using silver(I)/chiral phosphoric acid catalysis. A variety of alkyne-tethered indoles are suitable for this process. Mechanistic studies suggest that the in situ generated silver(I) chiral phosphate activates both the alkyne and the indole nucleophile in the initial cyclization step through an intermolecular hydrogen bond and the phosphate anion promotes proton transfer. In addition, further modifications of the cyclization products enabled stereochemistry-function studies of a series of bioactive indolines.
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Registered trials
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