ArticlePloS one2017
Paleoproteomics of the Dental Pulp: The plague paradigm.
Article in PloS one, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
13 citing papers in PubMed, 40 citations in OpenAlex.
- Proteomic Investigation of Human Dental Pulp to Identify Individuals Who Are Pregnant.Proteomics. Clinical applications · 2025Article
- Forensic Microbiology: When, Where and How.Microorganisms · 2024Review
- Paleomicrobiology: Tracking the past microbial life from single species to entire microbial communities.Microbial biotechnology · 2024Review
- Preservation of whole antibodies within ancient teeth.iScience · 2023Article
- Paleoserology points to Coronavirus as possible causative pathogens of the 'Russian flu'.Microbial biotechnology · 2022Article
- Palaeoserology - teeth put into ancient plagues and pandemics.Microbial biotechnology · 2022Article
- Immunohistochemical diagnosis of human infectious diseases: a review.Diagnostic pathology · 2022Review
- Advances in experimental and computational methodologies for the study of microbial-surface interactions at different omics levels.Frontiers in microbiology · 2022Review
- Ancient protein analysis in archaeology.Science advances · 2021Review
- Yersinia pestis: the Natural History of Plague.Clinical microbiology reviews · 2020Review
- Ancient dental pulp: Masterpiece tissue for paleomicrobiology.Molecular genetics & genomic medicine · 2020Review
- Molecular insights into an ancient form of Paget's disease of bone.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
- Two thousand years of epidemics in Marseille and the Mediterranean Basin.New microbes and new infections · 2018Article
Corrections and comments
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Chemical decomposition and fragmentation may limit the detection of ancient host and microbial DNA while some proteins can be detected for extended periods of time. We applied paleoproteomics on 300-year-old dental pulp specimens recovered from 16 individuals in two archeological funeral sites in France, comprising one documented plague site and one documented plague-negative site. The dental pulp paleoproteome of the 16 teeth comprised 439 peptides representative of 30 proteins of human origin and 211 peptides representative of 27 proteins of non-human origin. Human proteins consisted of conjunctive tissue and blood proteins including IgA immunoglobulins. Four peptides were indicative of three presumable Yersinia pestis proteins detected in 3/8 dental pulp specimens from the plague-positive site but not in the eight dental pulp specimens collected in the plague-negative site. Paleoproteomics applied to the dental pulp is a new and innovative approach to screen ancient individuals for the detection of blood-borne pathogens and host inflammatory response.
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Registered trials
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