Evidence map›Paper›PMID 28746366›Full record

ArticlePloS one2017

Synthesis, fungicidal evaluation and 3D-QSAR studies of novel 1,3,4-thiadiazole xylofuranose derivatives.

Guanghui Zong, Xiaojing Yan, Jiawei Bi, Rui Jiang, Yinan Qin, Huizhu Yuan, Huizhe Lu, Yanhong Dong, Shuhui Jin, Jianjun Zhang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in PloS one, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Guanghui ZongKey Laboratory of Pesticide Chemistry and Application Technology, College of Science, China Agricultural University, Beijing, China.
Xiaojing YanThe Institute of Plant Protection, Chinese Academy of Agricultural Sciences, Beijing, China.
Jiawei BiKey Laboratory of Pesticide Chemistry and Application Technology, College of Science, China Agricultural University, Beijing, China.
Rui JiangKey Laboratory of Pesticide Chemistry and Application Technology, College of Science, China Agricultural University, Beijing, China.
Yinan QinKey Laboratory of Pesticide Chemistry and Application Technology, College of Science, China Agricultural University, Beijing, China.
Huizhu YuanThe Institute of Plant Protection, Chinese Academy of Agricultural Sciences, Beijing, China.
Huizhe LuKey Laboratory of Pesticide Chemistry and Application Technology, College of Science, China Agricultural University, Beijing, China.
Yanhong DongKey Laboratory of Pesticide Chemistry and Application Technology, College of Science, China Agricultural University, Beijing, China.
Shuhui JinKey Laboratory of Pesticide Chemistry and Application Technology, College of Science, China Agricultural University, Beijing, China.
Jianjun ZhangKey Laboratory of Pesticide Chemistry and Application Technology, College of Science, China Agricultural University, Beijing, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

1,3,4-Thiadiazole and sugar-derived molecules have proven to be promising agrochemicals with growth promoting, insecticidal and fungicidal activities. In the research field of agricultural fungicide, applying union of active group we synthesized a new set of 1,3,4-thiadiazole xylofuranose derivatives and all of the compounds were characterized by 1H NMR and HRMS. In precise toxicity measurement, some of compounds exhibited more potent fungicidal activities than the most widely used commercial fungicide Chlorothalonil, promoting further research and development. Based on our experimental data, 3D-QSAR (three-dimensional quantitative structure-activity relationship) was established and investigated using comparative molecular field analysis (CoMFA) and comparative molecular similarity indices analysis (CoMSIA) techniques, helping to better understand the structural requirements of lead compounds with high fungicidal activity and environmental compatibility.

Indexed as

Quantitative Structure-Activity RelationshipFungiFungicides, IndustrialGlycosidesHydrogen BondingHydrophobic and Hydrophilic InteractionsMicrobial Sensitivity TestsModels, ChemicalModels, MolecularMolecular StructureNucleosidesProton Magnetic Resonance SpectroscopySpecies SpecificityStatic ElectricityThiadiazoles1,3,4-thiadiazoleFungicides, IndustrialGlycosidesNucleosidesThiadiazolesxylosides

Identifiers

PMID28746366
PMCPMC5528880

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.