ArticlePloS one2017
Synergistic effects of cognitive impairment on physical disability in all-cause mortality among men aged 80 years and over: Results from longitudinal older veterans study.
Article in PloS one, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 40 citations in OpenAlex.
- Mild Cognitive Impairment, Religiosity, Spirituality and all-Cause Mortality Among Chinese Older Adults in Ethnic Minority Communities.Journal of religion and health · 2026Article
- Adaptation Outcomes of a CAPABLE-Family Open-Label Pilot Study for Community-Dwelling Older Adults With Mild Cognitive Impairment/Early Dementia and Disability.Journal of applied gerontology : the official journal of the Southern Gerontological Society · 2026Article
- Associations of frailty and cognitive impairment with all-cause and cardiovascular mortality in older adults: a prospective cohort study from NHANES 2011-2014.BMC geriatrics · 2025Article
- The association of premorbid conditions with 6-month mortality in acutely admitted ICU patients over 80 years.Annals of intensive care · 2024Article
- Disability-Related Mortality Inequity in South Korea: Comparison in Terms of Seoul Metropolitan/Non-Metropolitan Areas and Income Levels.Healthcare (Basel, Switzerland) · 2024Article
- Discontinuation of cholinesterase inhibitor treatment in institutionalised patients with advanced dementia.European journal of hospital pharmacy : science and practice · 2022Observational
- Mediating effect of lower extremity muscle strength on the relationship between mobility and cognitive function in Chinese older adults: A cross-sectional study.Frontiers in aging neuroscience · 2022Article
- Cerebellar-limbic neurocircuit is the novel biosignature of physio-cognitive decline syndrome.Aging · 2020Article
- Multimorbidity and Cognitive Decline Over 14 Years in Older Americans.The journals of gerontology. Series A, Biological sciences and medical sciences · 2020Article
- Cognitive Function and Mortality: Results from Kaunas HAPIEE Study 2006-2017.International journal of environmental research and public health · 2020Article
- Association of cognitive impairment and elderly mortality: differences between two cohorts ascertained 6-years apart in China.BMC geriatrics · 2020Article
- The contribution of frailty, cognition, activity of daily life and comorbidities on outcome in acutely admitted patients over 80 years in European ICUs: the VIP2 study.Intensive care medicine · 2020Article
- Incident Mobility Disability, Mild Cognitive Impairment, and Mortality in Community-Dwelling Older Adults.Neuroepidemiology · 2019Article
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Authors and funding
6 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveWe evaluated effects of the interrelationship between physical disability and cognitive impairment on long-term mortality of men aged 80 years and older living in a retirement community in Taiwan.
methodsThis prospective cohort study enrolled older men aged 80 and older living in a Veterans Care Home. Those with confirmed diagnosis of dementia were excluded. All participants received comprehensive geriatric assessment, including sociodemographic data, Charlson's Comorbidity Index (CCI), geriatric syndromes, activities of daily living (ADL) using the Barthel index and cognitive function using the Mini-Mental State Examination (MMSE). Subjects were categorized into normal cognitive function, mild cognitive deterioration, and moderate-to-severe cognitive impairment and were further stratified by physical disability status. Kaplan-Meier log-rank test was used for survival analysis. After adjusting for sociodemographic characteristics and geriatric syndromes, Cox proportional hazards model was constructed to examine associations between cognitive function, disability and increased mortality risk.
resultsAmong 305 male subjects aged 85.1 ± 4.1 years, 89 subjects died during follow-up (mean follow-up: 1.87 ± 0.90 years). Kaplan-Meier unadjusted analysis showed reduced survival probability associated with moderate-to-severe cognitive status and physical disability. Mortality risk increased significantly only for physically disabled subjects with simultaneous mild cognitive deterioration (adjusted HR 1.951, 95% CI 1.036-3.673, p = 0.038) or moderate-to-severe cognitive impairment (aHR 2.722, 95% CI 1.430-5.181, p = 0.002) after adjusting for age, BMI, education levels, smoking status, polypharmacy, visual and hearing impairment, urinary incontinence, fall history, depressive symptoms and CCI. Mortality risk was not increased among physically independent subjects with or without cognitive impairment, and physically disabled subjects with intact cognition.
conclusionsPhysical disability is a major risk factor for all-cause mortality among men aged 80 years and older, and risk increased synergistically when cognitive impairment was present. Cognitive impairment alone without physical disability did not increase mortality risk in this population.
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