ArticleThe Pediatric infectious disease journal2018
Perinatal HIV Infection and Exposure and Their Association With Dental Caries in Nigerian Children.
Article in The Pediatric infectious disease journal, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 3 of them syntheses that pooled it.
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Who cites it
22 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Prevalence and associated risk indicators of early childhood caries in Nigeria: a systematic review and meta-analysis.BMC oral health · 2026Pooled it
- Prevalence of dental caries in the primary, mixed and permanent dentitions in Nigeria: A systematic review and meta-analysis.PloS one · 2026Pooled it
- Association between antiretroviral therapy and dental caries in children and adolescents with HIV: a systematic review and meta-analysis.BMC oral health · 2025Pooled it
- Trial
- Epigenetic Age Acceleration, Neurocognition and Oral Health in Nigerian Adolescents With and Without HIV.The Pediatric infectious disease journal · 2026Article
- The State of the Science on Chronic Comorbidities and Aging in Children and Adolescents with perinatally-acquired HIV.Current HIV/AIDS reports · 2025Review
- Oral health and behavioral problems in children living with and without HIV in South Africa.AIDS care · 2025Article
- Altered Surrogate Markers of Inflammation in Perinatal HIV-Exposed Children with Caries.JDR clinical and translational research · 2025Article
- Article
- Risk indicators for dental caries among preschoolers, school children/adolescents and adults in Nigeria: a scoping review.BMC oral health · 2025Article
- Residency as a determinant of oral health disparities in primary dentition among HIV-infected, HIV-exposed, and unexposed children in Kenya - findings from a cohort study.Critical public health · 2025Article
- Associations between sexual identity and caries risk indicators among adolescents and adults in Nigeria: implications for policy and actions.Frontiers in oral health · 2025Article
- Impact of perinatal HIV exposure and infection on salivary properties among Nigerian children.BMC oral health · 2024Article
- A 2-arm randomized controlled study to improve the oral health of children living with HIV in Nigeria: Protocol and study design.Contemporary clinical trials · 2024Article
- Impact of HIV on the Oral Microbiome of Children Living in Sub-Saharan Africa, Determined by Using anMicrobiology spectrum · 2023Article
- Age-specific associations with dental caries in HIV-infected, exposed but uninfected and HIV-unexposed uninfected children in Nigeria.BMC oral health · 2022Article
- Dental caries and its association with the oral microbiomes and HIV in young children-Nigeria (DOMHaIN): a cohort study.BMC oral health · 2021Article
- Oral Health Status of Young People Infected with HIV in High Epidemic Area of China.Journal of multidisciplinary healthcare · 2021Article
- HIV-Associated Interactions Between Oral Microbiota and Mucosal Immune Cells: Knowledge Gaps and Future Directions.Frontiers in immunology · 2021Review
- Immune status, and not HIV infection or exposure, drives the development of the oral microbiota.Scientific reports · 2020Article
Corrections and comments
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Authors and funding
10 authors.
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Abstract
backgroundAlthough HIV infection is associated with well-known oral pathologies, there remains a dearth of comparative studies aimed at determining the association between HIV infection/exposure and early childhood caries.
methodsThis is a cross-sectional study using a convenience sample of 3 groups of children receiving care at a tertiary care hospital in Nigeria. The groups include HIV infected (HI), HIV exposed but uninfected and HIV-unexposed and -uninfected children 6 through 72 months of age. Medical records were reviewed, and caregivers were interviewed for sociodemographic, maternal and birth factors as well as early feeding and dietary information. Oral examinations were performed by trained dentist examiners.
resultsOf 335 children enrolled, 33 (9.9%) presented with caries. In an adjusted analysis, compared with HIV-unexposed and -uninfected children, HI children had significantly greater odds of having caries (odds ratio = 2.58; 95% confidence interval: 1.04-6.40; P = 0.04), but there was no statistically significant difference in HIV exposed but uninfected children (odds ratio = 2.01; 95% confidence interval: 0.56-7.23; P = 0.28). Factors significantly associated with higher caries prevalence include low CD4 counts and percentage, older age, longer duration of breastfeeding and spontaneous membrane rupture during delivery.
conclusionsCaries was more prevalent in HI children. These findings support the need to target HI children for oral health prevention and treatment services particularly in Nigeria and other developing countries.
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