Evidence map›Paper›PMID 28745864›Full record

ReviewBiochemistry2017

Voltage Imaging: Pitfalls and Potential.

Rishikesh U Kulkarni, Evan W Miller

Abstract readReview
In one paragraph

Review in Biochemistry, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 61 papers.

0numbers the graph read from it
0cells of the map it votes in
61citing papers in PubMed
6.2field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

61 citing papers in PubMed, 102 citations in OpenAlex.

  1. Article
  2. Review
  3. Absolute voltage mapping using dynamic photocycle control.bioRxiv : the preprint server for biology · 2026
    Article
  4. Article
  5. Article
  6. Review
  7. Article
  8. Review
  9. Review
  10. Review
  11. Article
  12. Article
  13. Article
  14. Review
  15. Review
  16. Article
  17. Optical Estimation of Bioelectric Patterns in Living Embryos.Methods in molecular biology (Clifton, N.J.) · 2024
    Article
  18. Article
  19. Review
  20. Review

1 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Rishikesh U KulkarniDepartment of Chemistry, ‡Department of Molecular and Cell Biology, and §Helen Wills Neuroscience Institute, University of California , Berkeley, California 94720, United States.
Evan W MillerDepartment of Chemistry, ‡Department of Molecular and Cell Biology, and §Helen Wills Neuroscience Institute, University of California , Berkeley, California 94720, United States.ORCID 0000-0002-6556-7679
University of California, Berkeley · US

Funding

Univ of Calif Berkeley Chemistry-Biology Interface ProgramT32GM066698 · NIGMS · UNIVERSITY OF CALIFORNIA BERKELEY · PI CHANG, CHRISTOPHER J., FRANCIS, MATTHEW B · 2004 to 2023
$7.5M
Interrogating Neuronal Membrane Potential Dynamics with Optical Voltage SensorsR01NS098088 · NINDS · UNIVERSITY OF CALIFORNIA BERKELEY · PI Evan Walker Miller · 2017 to 2026
$4.4M
New Chemical Tools for Exploring Cellular PhysiologyR35GM119855 · NIGMS · UNIVERSITY OF CALIFORNIA BERKELEY · PI MILLER, EVAN WALKER · 2016 to 2020
$1.3M
NIGMS NIH HHS R35 GM119855NIGMS NIH HHS T32 GM066698NINDS NIH HHS R01 NS098088
6 · The paper itself

Abstract

Optical methods for interrogating membrane potential changes in neurons promise to revolutionize our ability to dissect the activity of individual cells embedded in neural circuits underlying behavior and sensation. A number of voltage imaging strategies have emerged in the past few years. This Perspective discusses developments in both small-molecule and genetically encoded fluorescent indicators of membrane potential. We survey recent advances in small-molecule fluorescent indicators that rely on photoinduced electron transfer to sense voltage as well as refinements of voltage-sensitive fluorescent proteins and new opsin-based strategies for monitoring voltage changes. We compare the requirements of fluorescent voltage indicators to those for more canonical Ca

Indexed as

Membrane PotentialsAnimalsFluorescent DyesLuminescent ProteinsNeuronsOpsinsOptical ImagingFluorescent DyesLuminescent ProteinsOpsins

Identifiers

PMID28745864
PMCPMC5715730
OpenAlexW2736996438

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.