Evidence map›Paper›PMID 28745549›Full record

ArticlePharmacogenomics2017

Prior opioid exposure influences parents' sharing of their children's CYP2D6 research results.

Melanie F Myers, Xue Zhang, Brooke McLaughlin, Diane Kissell, Cassandra L Perry, Matthew Veerkamp, Kejian Zhang, Ingrid A Holm, Cynthia A Prows

Open access · greenAbstract read
In one paragraph

Article in Pharmacogenomics, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.4field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 4 citations in OpenAlex.

  1. Implementation of CYP2D6-guided opioid therapy at Cincinnati Children's Hospital Medical Center.American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists · 2023
    Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 1 country.

Melanie F MyersDivision of Human Genetics, Department of Pediatrics, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA.
Xue ZhangDivision of Human Genetics, Department of Pediatrics, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA.
Brooke McLaughlinDivision of Human Genetics, Department of Pediatrics, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA.
Diane KissellDivision of Human Genetics, Department of Pediatrics, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA.
Cassandra L PerryDepartment of Biomedical Informatics, Harvard Medical School, Boston, MA 02115, USA.
Matthew VeerkampCenter for Autoimmune Genomics & Etiology, Department of Pediatrics, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA.
Kejian ZhangDivision of Human Genetics, Department of Pediatrics, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA.
Ingrid A HolmDivision of Genetics & Genomics & The Manton Center for Orphan Disease Research, Department of Medicine, Boston Children's Hospital, Boston, MA 02115, USA.
Cynthia A ProwsDivision of Human Genetics, Department of Pediatrics, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA.
Cincinnati Children's Hospital Medical Center · USBoston Children's Hospital · USHarvard University · USUniversity of Cincinnati Medical Center · US

Funding

Better Outcomes for Children: Promoting Excellence in Healthcare Genomics to Inform PolicyU01HG008666 · NHGRI · CINCINNATI CHILDRENS HOSP MED CTR · PI HARLEY, JOHN BARKER · 2015 to 2019
$4.2M
Better Outcomes for Children: GWAS & PheWAS in eMERGEII.U01HG006828 · NHGRI · CINCINNATI CHILDRENS HOSP MED CTR · PI HARLEY, JOHN BARKER, HOLM, INGRID ADELE · 2012 to 2014
$4.0M
NHGRI NIH HHS U01 HG006828NHGRI NIH HHS U01 HG008666
6 · The paper itself

Abstract

aimTo determine parents' use of their children's CYP2D6 research result. We hypothesized that perceived utility, likelihood of sharing and actual sharing of results would differ between parents with children previously exposed (cases) or unexposed (controls) to opioids.

methodsWe returned results by phone (baseline). We surveyed parents about perceived utility and likelihood of sharing their child's research result at baseline, and actual sharing at 3 and 12 months.

resultsCases were more likely than controls to agree that they (p = 0.022) and the doctors (p = 0.041) could use the results to care for their child, to report higher likelihood of sharing (p = 0.042) and to actually share results with the child's doctor (p = 0.026).

conclusionPrior opioid exposure influenced perceived clinical utility and sharing behaviors.

Indexed as

AdolescentAdultAnalgesics, OpioidChildCytochrome P-450 CYP2D6FemaleHumansMaleMiddle AgedParentsPerceptionSurveys and QuestionnairesAnalgesics, OpioidCytochrome P-450 CYP2D6clinic utilityCYD2D6pediatricpharmacogenetics testingreturn of resultssharing of results

Identifiers

PMID28745549
PMCPMC5827812
OpenAlexW2739065948

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.