ArticleEpilepsia2017
Voxel-based magnetic resonance image postprocessing in epilepsy.
Article in Epilepsia, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed, 50 citations in OpenAlex.
- Volume-inflation registration (INFREG) for morphometric analysis of human focal cortical dysplasia type II.iScience · 2026Article
- Sleep magnetoencephalography enhances detection and source imaging of seizures and fast oscillations in focal cortical dysplasia.Epilepsia · 2026Article
- Potential role of MELD and MAP18 in patients with structural temporal lobe epilepsy.Neuroradiology · 2025Article
- Voxel-based and surface-based cortical morphometric MRI applications for identifying the epileptogenic zone: A narrative review.Epilepsia open · 2025Review
- SimultaneousNeuroradiology · 2025Article
- Combined MRI morphometry and source imaging guide placement of stereo-EEG electrodes in focal epilepsy with subtle or absent lesions.Frontiers in neurology · 2025Article
- Advances in magnetic resonance imaging for the assessment of paediatric focal epilepsy: a narrative review.Translational pediatrics · 2024Review
- Focal cortical dysplasia lesion segmentation using multiscale transformer.Insights into imaging · 2024Article
- Deep learning-based automated lesion segmentation on pediatric focal cortical dysplasia II preoperative MRI: a reliable approach.Insights into imaging · 2024Article
- Can Brain Volume-Driven Characteristic Features Predict the Response of Alzheimer's Patients to Repetitive Transcranial Magnetic Stimulation? A Pilot Study.Brain sciences · 2024Article
- Differences of white matter structure for diffusion kurtosis imaging using voxel-based morphometry and connectivity analysis.BJR open · 2024Article
- Article
- Gray and White Matter Voxel-Based Morphometry of Alzheimer's Disease With and Without Significant Cerebrovascular Pathologies.Neuroscience insights · 2024Article
- Multimodal combination of neuroimaging methods for localizing the epileptogenic zone in MR-negative epilepsy.Scientific reports · 2022Article
- Value of ultra-high field MRI in patients with suspected focal epilepsy and negative 3 T MRI (EpiUltraStudy): protocol for a prospective, longitudinal therapeutic study.Neuroradiology · 2022Article
- Review
- Automatic Detection of Focal Cortical Dysplasia Type II in MRI: Is the Application of Surface-Based Morphometry and Machine Learning Promising?Frontiers in human neuroscience · 2021Article
- 7T MRI with post-processing for the presurgical evaluation of pharmacoresistant focal epilepsy.Therapeutic advances in neurological disorders · 2021Article
- Integrative analysis of non-targeted lipidomic data and brain structural imaging identifies phosphatidylethanolamine associated with epileptogenesis.Metabolomics : Official journal of the Metabolomic Society · 2020Article
- Voxel-Based Morphometry-from Hype to Hope. A Study on Hippocampal Atrophy in Mesial Temporal Lobe Epilepsy.AJNR. American journal of neuroradiology · 2020Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
Abstract
objectiveAlthough the general utility of voxel-based processing of structural magnetic resonance imaging (MRI) data for detecting occult lesions in focal epilepsy is established, many differences exist among studies, and it is unclear which processing method is preferable. The aim of this study was to compare the ability of commonly used methods to detect epileptogenic lesions in magnetic resonance MRI-positive and MRI-negative patients, and to estimate their diagnostic yield.
methodsWe identified 144 presurgical focal epilepsy patients, 15 of whom had a histopathologically proven and MRI-visible focal cortical dysplasia; 129 patients were MRI negative with a clinical hypothesis of seizure origin, 27 of whom had resections. We applied four types of voxel-based morphometry (VBM), three based on T1 images (gray matter volume, gray matter concentration, junction map [JM]) and one based on normalized fluid-attenuated inversion recovery (nFSI). Specificity was derived from analysis of 50 healthy controls.
resultsThe four maps had different sensitivity and specificity profiles. All maps showed detection rates for focal cortical dysplasia patients (MRI positive and negative) of >30% at a strict threshold of p < 0.05 (family-wise error) and >60% with a liberal threshold of p < 0.0001 (uncorrected), except for gray matter volume (14% and 27% detection rate). All maps except nFSI showed poor specificity, with high rates of false-positive findings in controls. In the MRI-negative patients, absolute detection rates were lower. A concordant nFSI finding had a significant positive odds ratio of 7.33 for a favorable postsurgical outcome in the MRI-negative group. Spatial colocalization of JM and nFSI was rare, yet showed good specificity throughout the thresholds. SIGNIFICANCE: All VBM variants had specific diagnostic properties that need to be considered for an adequate interpretation of the results. Overall, structural postprocessing can be a useful tool in presurgical diagnostics, but the low specificity of some maps has to be taken into consideration.
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Registered trials
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