Evidence map›Paper›PMID 28744870›Full record

ArticleMedical physics2017

Fast dose optimization for rotating shield brachytherapy.

Myung Cho, Xiaodong Wu, Hossein Dadkhah, Jirong Yi, Ryan T Flynn, Yusung Kim, Weiyu Xu

Abstract read
In one paragraph

Article in Medical physics, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Systematic Review of Intensity-Modulated Brachytherapy (IMBT): Static and Dynamic Techniques.International journal of radiation oncology, biology, physics · 2019
    Pooled it
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Myung ChoDepartment of Electrical and Computer Engineering, University of Iowa, 4016 Seamans Center, Iowa City, IA, 52242, USA.
Xiaodong WuDepartment of Electrical and Computer Engineering, University of Iowa, 4016 Seamans Center, Iowa City, IA, 52242, USA.
Hossein DadkhahDepartment of Biomedical Engineering, University of Iowa, 1402 Seamans Center, Iowa City, IA, 52242, USA.
Jirong YiDepartment of Electrical and Computer Engineering, University of Iowa, 4016 Seamans Center, Iowa City, IA, 52242, USA.
Ryan T FlynnDepartment of Radiation Oncology, University of Iowa, 200 Hawkins Drive, Iowa City, IA, 52242, USA.
Yusung KimDepartment of Radiation Oncology, University of Iowa, 200 Hawkins Drive, Iowa City, IA, 52242, USA.
Weiyu XuDepartment of Electrical and Computer Engineering, University of Iowa, 4016 Seamans Center, Iowa City, IA, 52242, USA.

Funding

Viral VectorP30CA086862 · NCI · UNIVERSITY OF IOWA · PI Douglas Robert Spitz · 2000 to 2026
$70.0M
Developing a Treatment Planning System for Next Generation Rotating-Shield BrachytherapyR01EB020665 · NIBIB · UNIVERSITY OF IOWA · PI WU, XIAODONG · 2015 to 2018
$1.5M
A New Prostate Cancer Treatment to Improve Outcomes and Reduce Side-effectsR41CA210737 · NCI · PXALPHA, LLC · PI FLYNN, RYAN THOMAS · 2016 to 2016
$225k
NCI NIH HHS R41 CA210737NIBIB NIH HHS R01 EB020665
6 · The paper itself

Abstract

purposeTo provide a fast computational method, based on the proximal graph solver (POGS) - A convex optimization solver using the alternating direction method of multipliers (ADMM), for calculating an optimal treatment plan in rotating shield brachytherapy (RSBT). RSBT treatment planning has more degrees of freedom than conventional high-dose-rate brachytherapy due to the addition of emission direction, and this necessitates a fast optimization technique to enable clinical usage.

methodsThe multi-helix RSBT (H-RSBT) delivery technique was investigated for five representative cervical cancer patients. Treatment plans were generated for all patients using the POGS method and the commercially available solver IBM ILOG CPLEX. The rectum, bladder, sigmoid colon, high-risk clinical target volume (HR-CTV), and HR-CTV boundary were the structures included in our optimization, which applied an asymmetric dose-volume optimization with smoothness control. Dose calculation resolution was 1 × 1 × 3 mm

resultsFor each patient, HR-CTV D

conclusionsPOGS reduced treatment plan optimization time approximately 18 times for RSBT with similar HR-CTV D

Indexed as

BrachytherapyRadiation DosageRotationHumansNeoplasmsRadiotherapy DosageRadiotherapy Planning, Computer-AssistedTime Factorsbrachytherapycancer treatment planninggynecological canceroptimizationrotating shield brachytherapy

Identifiers

PMID28744870
PMCPMC5943050

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.