Evidence map›Paper›PMID 28744806›Full record

ArticleImmunologic research2017

Interleukin-10 production and T cell-suppressive capacity in B cell subsets from atherosclerotic apoE

Héctor Rincón-Arévalo, Janny Villa-Pulgarín, Jorge Tabares, Mauricio Rojas, Gloria Vásquez, José R Ramírez-Pineda, Diana Castaño, Lina M Yassin

Abstract read
PubMed Publisher
In one paragraph

Article in Immunologic research, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.4field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 8 citations in OpenAlex.

  1. Review
  2. Review
  3. Review
  4. Low frequency of IL-10Heliyon · 2020
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Héctor Rincón-ArévaloGrupo de Inmunología Celular e Inmunogenética, Instituto de Investigaciones Médicas, Facultad de Medicina, Universidad de Antioquia UdeA, Calle 70 No 52-21, Medellín, Colombia.
Janny Villa-PulgarínGrupo Inmunomodulación, Instituto de Investigaciones Médicas, Facultad de Medicina, Universidad de Antioquia UdeA, Calle 70 No 52-21, Medellín, Colombia.
Jorge TabaresGrupo Inmunomodulación, Instituto de Investigaciones Médicas, Facultad de Medicina, Universidad de Antioquia UdeA, Calle 70 No 52-21, Medellín, Colombia.
Mauricio RojasGrupo de Inmunología Celular e Inmunogenética, Instituto de Investigaciones Médicas, Facultad de Medicina, Universidad de Antioquia UdeA, Calle 70 No 52-21, Medellín, Colombia.
Gloria VásquezGrupo de Inmunología Celular e Inmunogenética, Instituto de Investigaciones Médicas, Facultad de Medicina, Universidad de Antioquia UdeA, Calle 70 No 52-21, Medellín, Colombia.
José R Ramírez-PinedaGrupo Inmunomodulación, Instituto de Investigaciones Médicas, Facultad de Medicina, Universidad de Antioquia UdeA, Calle 70 No 52-21, Medellín, Colombia.
Diana CastañoGrupo de Inmunología Celular e Inmunogenética, Instituto de Investigaciones Médicas, Facultad de Medicina, Universidad de Antioquia UdeA, Calle 70 No 52-21, Medellín, Colombia. diana.castano@udea.edu.co.ORCID 0000-0002-5697-5603
Lina M YassinGrupo de Investigaciones Biomédicas Uniremington, Corporación Universitaria Remington, Medellín, Colombia. yascatorce@yahoo.com.
Universidad de Antioquia · COCorporación Universitaria Remington · CO

Funding

Colciencias 111554431390Colciencias Joven InvestigadorUniversidad de Antioquia Sostenibilidad
6 · The paper itself

Abstract

The evidence regarding the role of regulatory B cells (Breg) in atherosclerosis are scarce, and there are contradictory data about their atheroprotective properties. Due to the demonstrated protective function of Breg in different inflammatory diseases mainly through interleukin-10 (IL-10) production, the knowledge of their participation in atherosclerosis immunopathology would be very valuable. To further study which B cell subsets participate in IL-10 production and their regulatory role, splenocytes from apolipoprotein-E-deficient mice were evaluated by ex vivo and in vitro cultures. Atherosclerotic mice had increased frequency of IL-10

Indexed as

AnimalsAtherosclerosisB-Lymphocytes, RegulatoryB-Lymphocyte SubsetsCell ProliferationCells, CulturedDiet, High-FatDisease Models, AnimalFemaleHumansImmune ToleranceInterferon-gammaInterleukin-10MiceMice, Inbred C57BLMice, Knockout, ApoEInterferon-gammaInterleukin-10Tumor Necrosis Factor-alphaApolipoprotein-E-deficient miceAtherosclerosisFollicular B cellsIl-10Regulatory B cells

Identifiers

PMID28744806
OpenAlexW2736400451

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.