ArticleJournal of neurology2017
Mortality after primary intracerebral hemorrhage in relation to post-stroke seizures.
Article in Journal of neurology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.
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Who cites it
16 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Relationship Between Mortality and Seizures After Intracerebral Hemorrhage: A Systematic Review and Meta-Analysis.Frontiers in neurology · 2022Pooled it
- Prophylactic Antiepileptic Drugs in Nontraumatic Intracerebral Hemorrhage: A Network Meta-Analysis.Neurocritical care · 2026Article
- Development and external validation of the LEAN score to predict late seizures after intracerebral haemorrhage.European stroke journal · 2026Article
- Development and external validation of the LEAN score to predict late seizures after intracerebral haemorrhage.European stroke journal · 2025Article
- Risk factors of posthemorrhagic seizure in spontaneous intracerebral hemorrhage.Neurosurgical review · 2025Article
- Long-Term Outcomes in Patients With Spontaneous Cerebellar Hemorrhage: An International Cohort Study.Stroke · 2024Article
- Incidence of mortality and risk factors among adult stroke patients in public hospitals Jigjiga town Somali region, Ethiopia: Cohort study design.SAGE open medicine · 2024Article
- Predictors of unprovoked seizures in intracerebral hemorrhages.Acta neurologica Belgica · 2023Article
- Risk factors that predict delayed seizure detection on continuous electroencephalogram (cEEG) in a large sample size of critically ill patients.Epilepsia open · 2022Article
- In-hospital mortality and its predictors among adult stroke patients admitted in Debre Markos Comprehensive Specialized Hospital, Northwest Ethiopia.SAGE open medicine · 2022Article
- New-onset seizures after cranioplasty-a different view on a putatively frequently observed phenomenon.Acta neurochirurgica · 2021Article
- Risk of Post-stroke Epilepsy Following Stroke-Associated Acute Symptomatic Seizures.Frontiers in aging neuroscience · 2021Article
- MicroRNA Regulatory Network as Biomarkers of Late Seizure in Patients with Spontaneous Intracerebral Hemorrhage.Molecular neurobiology · 2020Article
- Clinical Profile and Outcomes of Early Seizures in Asian Patients With Acute Intracerebral Hemorrhage.Journal of acute medicine · 2019Article
- Seizures Do Not Affect Disability and Mortality Outcomes of Stroke: A Population-Based Study.Journal of clinical medicine · 2019Article
- Gender differences in long-term mortality after spontaneous intracerebral hemorrhage in southern Portugal.Porto biomedical journalArticle
Corrections and comments
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Seizures after intracerebral hemorrhage are repeatedly seen. Whether the development of seizures after intracerebral hemorrhage affects survival in the long term is unknown. This study aims to determine the relation between seizures (i.e., with and without anti-epileptic therapy) and long-term mortality risk in a large patient population with intracerebral hemorrhage. We retrospectively included patients with a non-traumatic ICH in all three hospitals in the South Limburg region in the Netherlands between January 1st 2004 and December 31st 2009, and we assessed all-cause mortality until March 14th 2016. Patient who did not survive the first seven days after intracerebral hemorrhage were excluded from analyses. We used Cox multivariate analyses to determine independent predictors of mortality. Of 1214 patients, 783 hemorrhagic stroke patients fulfilled the inclusion criteria, amongst whom 37 (4.7%) patients developed early seizures (within 7 days after hemorrhage) and 77 (9.8%) developed late seizures (more than 7 days after hemorrhage). Seizure development was not significantly related to mortality risk after correction for conventional vascular risk factors and hemorrhage severity. However, we found a small but independent relation between the use of anti-epileptic drugs and a lower long-term mortality (HR = 0.32, 95% CI 0.11-0.91). In our large population, seizures and epilepsy did not relate independently to an increased mortality risk after hemorrhage.
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