Evidence map›Paper›PMID 28744761›Full record

ArticleJournal of autism and developmental disorders2017

Olfactory Processing in Male Children with Autism: Atypical Odor Threshold and Identification.

Filippo Muratori, Alessandro Tonacci, Lucia Billeci, Tiziana Catalucci, Roberta Igliozzi, Sara Calderoni, Antonio Narzisi

Erratum issued Registry-linked trialAbstract read
PubMed Publisher
In one paragraph

Article in Journal of autism and developmental disorders, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. It is linked to trial NCT06335030 (Relationship Between Sensory and Behavioral Aspects With Particular Attention to Food Selectivity in Children With Autism Spectrum Disorder and Parental Stress Perceived), which is not on this map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
3.2field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06335030 unknown statusnot on this mapstarted 2021, after this paper: background citation

Relationship Between Sensory and Behavioral Aspects With Particular Attention to Food Selectivity in Children With Autism Spectrum Disorder and Parental Stress Perceived

Typeobservational_patient_registrySponsorIRCCS Fondazione Stella MarisRan2021 to 2024Enrolled50ConditionsAutism Spectrum Disorder
3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 46 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Review
  5. Anterior piriform cortex dysfunction underlies autism spectrum disorders-related olfactory deficits in Fmr1 conditional deletion mice.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2025
    Article
  6. Article
  7. Article
  8. Review
  9. Article
  10. Review
  11. Article
  12. Review
  13. Exposure to GABAFrontiers in psychiatry · 2022
    Article
  14. Article
  15. Article
  16. Review
  17. Article
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Filippo MuratoriDepartment of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy.
Alessandro TonacciNational Research Council of Italy, Institute of Clinical Physiology, IFC-CNR, Via Moruzzi 1, 56124, Pisa, Italy. atonacci@ifc.cnr.it.ORCID http://orcid.org/0000-0001-8335-5541
Lucia BilleciIRCCS Stella Maris Foundation, Pisa, Italy.
Tiziana CatalucciIRCCS Stella Maris Foundation, Pisa, Italy.
Roberta IgliozziIRCCS Stella Maris Foundation, Pisa, Italy.
Sara CalderoniDepartment of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy.
Antonio NarzisiIRCCS Stella Maris Foundation, Pisa, Italy.
Fondazione Stella Maris · ITUniversity of Pisa · ITIstituto di Fisiologia Clinica · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Sensory issues are of great interest in ASD diagnosis. However, their investigation is mainly based on external observation (parent reports), with methodological limitations. Unobtrusive olfactory assessment allows studying autism neurosensoriality. Here, 20 male children with high-functioning ASD and 20 matched controls were administered a complete olfactory test battery, assessing olfactory threshold, identification and discrimination. ASD children show lower sensitivity (p = 0.041), lower identification (p = 0.014), and intact odor discrimination (p = 0.199) than controls. Comparing olfactory and clinical scores, a significant correlation was found in ASD between olfactory threshold and the CBCL social problems (p = 0.011) and aggressive behavior (p = 0.012) sub-scales. The pattern featuring peripheral hyposensitivity, high-order difficulties in odor identification and regular subcortical odor discrimination is discussed in light of hypo-priors hypothesis for autism.

Indexed as

OdorantsAdolescentAutistic DisorderChildCohort StudiesHumansMaleOlfaction DisordersOlfactory PathwaysSensory ThresholdsSmellAutismHypo-priors hypothesisOlfactory functioningSensory processing

Identifiers

PMID28744761
OpenAlexW2739175576

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.