ArticleInternational journal of clinical oncology2018
Impact of major different variants of papillary thyroid microcarcinoma on the clinicopathological characteristics: the study of 1041 cases.
Article in International journal of clinical oncology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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12 citing papers in PubMed, 25 citations in OpenAlex.
- Frequency of Thyroid Cancer in Multinodular Goiter Undergoing Thyroidectomy in Tertiary Care Centre in Pakistan: A Cross-Sectional Analysis.Health science reports · 2026Article
- Interstitial Fibrosis as a Common Counterpart of Histopathological Risk Factors in Papillary Thyroid Microcarcinoma: A Retrospective Analysis.Diagnostics (Basel, Switzerland) · 2024Article
- Article
- Subcentimetric papillary thyroid carcinoma with extensive lymph node and brain metastasis: case report and review of literature.Endocrinology, diabetes & metabolism case reports · 2023Article
- Diagnostic accuracy of dual-energy computed tomography-based nomogram for differentiating papillary thyroid microcarcinomas from micronodular goiters.Quantitative imaging in medicine and surgery · 2023Article
- Nomogram based on spectral CT quantitative parameters and typical radiological features for distinguishing benign from malignant thyroid micro-nodules.Cancer imaging : the official publication of the International Cancer Imaging Society · 2023Article
- Classic and Follicular Variant of Papillary Thyroid Microcarcinoma: 2 Different Phenotypes Beyond Tumor Size.Journal of the Endocrine Society · 2022Article
- Comparative BRAF V600E immunohistochemical expression in differentiated thyroid tumors with papillary features.Journal of medicine and life · 2022Article
- Which papillary thyroid microcarcinoma should be treated as "true cancer" and which as "precancer"?World journal of surgical oncology · 2019Article
- Small Cell Carcinoma: a Rare Subtype of Thyroid Cancer with Unanticipated Prognosis.Current medical science · 2019Article
- Thyroidectomy as Treatment of Choice for Differentiated Thyroid Cancer.International journal of surgical oncology · 2019Article
- The impact of minimal extrathyroidal extension in the recurrence of papillary thyroid cancer patients.Archives of endocrinology and metabolismArticle
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Authors and funding
9 authors at 1 institution in 1 country.
Funding
Abstract
backgroundThe incidence of papillary thyroid microcarcinoma (PTMC) has been increasing globally in the past few decades. PTMC does not have a distinctive morphology that results in differences in biological behavior. The aim of this study was to classify PTMCs according to the morphological features and explore the relationship with clinicopathological characteristics. Additionally, we sought to evaluate whether different variants of PTMC can be an independent predictor for lymph mode metastasis when considering other risk factors.
methodsBetween December 2014 and December 2015, 1041 PTMC cases undergoing surgical resection at Tianjin Medical University Cancer Institute and Hospital were reviewed retrospectively. Statistical analysis was performed to investigate the independent factors for lymph node metastasis in PTMC.
resultsConventional variant PTMC (CPTMC), follicular variant PTMC (FPTMC), and encapsulated variant PTMC (EnPTMC) were major variants in PTMC, collectively accounting for 96.7% of the entire PTMC cohort.There were significant differences in clinicopathological characteristics among the three major variants. The frequency of aggressive parameters was significantly different among the three variants, including tumor size, minimal extrathyroidal extension (minimal ETE), and lymph node metastasis (all P < 0.05), being highest in CPTMC, lowest in EnPTMC, and intermediate in FPTMC. FPTMC (OR = 0.642, P = 0.003) and EnPTMC (OR = 0.540, P = 0.041) were independent protective factors for lymph node metastasis (LNM). In contrast, male gender (OR = 1.836, P = 0.000), age less than 45 years (OR = 1.457, P = 0.009), tumor size greater than 0.5 cm (OR = 1.453, P = 0.007), calcification (OR = 1.465, P = 0.016), minimal ETE (OR = 1.801, P = 0.001), and multifocality (OR = 1.721, P = 0.000) were independent risk factors for LNM.
conclusionsThe present study demonstrates the distinct biological behaviors of the three major PTMC variants and establishes an aggressive order of CPTMC ≫ FPTMC > EnPTMC. It is necessary to take into consideration variant-related risks and other independent predictors for the determination of lymphadenectomy in patients with PTMC.
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