Evidence map›Paper›PMID 28744706›Full record

ReviewCurrent genetics2018

The evolution of a G1/S transcriptional network in yeasts.

Adi Hendler, Edgar M Medina, Nicolas E Buchler, Robertus A M de Bruin, Amir Aharoni

Abstract readReview
PubMed Publisher
In one paragraph

Review in Current genetics, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
0.8field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 21 citations in OpenAlex.

  1. Article
  2. Journal of fungi (Basel, Switzerland) · 2025
    Article
  3. Article
  4. Article
  5. Control of Gene Expression via the Yeast CWI Pathway.International journal of molecular sciences · 2022
    Review
  6. Regulation of sphingolipid synthesis by the G1/S transcription factor Swi4.Biochimica et biophysica acta. Molecular and cell biology of lipids · 2021
    Article
  7. Article
  8. Review
  9. Review
  10. Article
  11. Article
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 3 countries.

Adi HendlerDepartment of Life Sciences and the National Institute for Biotechnology in the Negev, Ben-Gurion University of the Negev, 84105, Beersheba, Israel.
Edgar M MedinaDepartment of Biology, Duke University, Durham, NC, USA.
Nicolas E BuchlerDepartment of Biology, Duke University, Durham, NC, USA. nicolas.buchler@duke.edu.
Robertus A M de BruinMRC Laboratory for Molecular Cell Biology, University College London, London, WC1E 6BT, UK. r.debruin@ucl.ac.uk.
Amir AharoniDepartment of Life Sciences and the National Institute for Biotechnology in the Negev, Ben-Gurion University of the Negev, 84105, Beersheba, Israel. aaharoni@bgu.ac.il.ORCID http://orcid.org/0000-0003-2701-6996
Ben-Gurion University of the Negev · ILDuke University · USMRC Laboratory for Molecular Cell Biology · GB

Funding

Rewiring the yeast brain: Redundancy and interference in genetic networksDP2OD008654 · OD · DUKE UNIVERSITY · PI BUCHLER, NICOLAS EMILE · 2011 to 2011
$2.4M
Cancer Research UK 20147NIH HHS DP2 OD008654
6 · The paper itself

Abstract

The G1-to-S cell cycle transition is promoted by the periodic expression of a large set of genes. In Saccharomyces cerevisiae G1/S gene expression is regulated by two transcription factor (TF) complexes, the MBF and SBF, which bind to specific DNA sequences, the MCB and SCB, respectively. Despite extensive research little is known regarding the evolution of the G1/S transcription regulation including the co-evolution of the DNA binding domains with their respective DNA binding sequences. We have recently examined the co-evolution of the G1/S TF specificity through the systematic generation and examination of chimeric Mbp1/Swi4 TFs containing different orthologue DNA binding domains in S. cerevisiae (Hendler et al. in PLoS Genet 13:e1006778. doi: 10.1371/journal.pgen.1006778 , 2017). Here, we review the co-evolution of G1/S transcriptional network and discuss the evolutionary dynamics and specificity of the MBF-MCB and SBF-SCB interactions in different fungal species.

Indexed as

Biological EvolutionGene Expression Regulation, FungalGene Regulatory NetworksTranscription, GeneticEvolution, MolecularG1 PhaseSaccharomyces cerevisiaeSaccharomyces cerevisiae ProteinsS PhaseTranscription FactorsYeastsMBP1 protein, S cerevisiaeSaccharomyces cerevisiae ProteinsSBF protein, S cerevisiaeTranscription FactorsCell cycleEvolutionG1-to-S transitionGene expressionMBF and SBF

Identifiers

PMID28744706
OpenAlexW2737643008

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.