ArticleDocumenta ophthalmologica. Advances in ophthalmology2017
Safety of intravitreal clindamycin in albino rabbit eyes.
Article in Documenta ophthalmologica. Advances in ophthalmology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed, 8 citations in OpenAlex.
- Anti-angiogenic activity and safety of intraocular application of triterpenes.Documenta ophthalmologica. Advances in ophthalmology · 2021Article
- Assessment of the safety of intravitreal injection of metoprolol tartrate in rabbits.Documenta ophthalmologica. Advances in ophthalmology · 2021Article
- Intravitreal Trimethoprim and Sulfamethoxazole Toxicity to the Retina of Albino Rabbits.Translational vision science & technology · 2018Article
- Retinal Toxicity of Intravitreal Injection of Ziv-Aflibercept in Albino Rabbits.Translational vision science & technology · 2018Article
- Macular Infarction following Intravitreal Clindamycin Injection : A Case Report.Journal of current ophthalmologyArticle
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeTo study the potential toxic effects of intravitreal clindamycin on the retina of albino rabbits, by assessing functional and morphological retinal changes.
methodsEight albino rabbits were included in the study. In each rabbit, 1 mg/0.1 ml clindamycin was injected into the vitreous of the right (experimental) eye, and 0.1 ml saline was injected into the vitreous of the left (control) eye. The electroretinogram (ERG) was recorded before injection, 3 days, 1, 2, and 4 weeks post-injection. The visual evoked potential (VEP) was recorded 4 weeks post-injection. Clinical examination was conducted at all time points. The eyes were enucleated at the termination of the follow-up period in order to prepare the retinas for histology in order to assess retinal structure.
resultsERG and VEP responses that were recorded from the experimental eye at different times following intravitreal clindamycin injection were very similar to the corresponding responses that were recorded from the control eyes. Clinical examination was normal in all eyes, and no histological damage was observed.
conclusionsIntravitreal injection of 1 mg clindamycin does not cause functional or morphological signs of retinal toxicity in albino rabbits, during a period of 4 weeks post-injection. These findings support the clinical use of 1 mg intravitreal clindamycin.
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