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Evolution of Cost-Free Resistance under Fluctuating Drug Selection in
Article in mSphere. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed, 53 citations in OpenAlex.
- Impact of multidrug resistance on the virulence and fitness of Pseudomonas aeruginosa: a microbiological and clinical perspective.Infection · 2024Review
- Unpredictability of the Fitness Effects of Antimicrobial Resistance Mutations Across Environments in Escherichia coli.Molecular biology and evolution · 2024Article
- Range expansion can promote the evolution of plastic generalism in coarse-grained landscapes.Evolution letters · 2024Article
- Competitive interactions facilitate resistance development against antimicrobials.Applied and environmental microbiology · 2023Article
- Fitness Costs of Antibiotic Resistance Impede the Evolution of Resistance to Other Antibiotics.ACS infectious diseases · 2023Article
- The balance between antibiotic resistance and fitness/virulence inFrontiers in microbiology · 2023Review
- Golden Gate Assembly of Aerobic and Anaerobic Microbial Bioreporters.Applied and environmental microbiology · 2022Article
- The cost of evolved constitutiveEcology and evolution · 2021Article
- Gene-Gene Interactions Dictate Ciprofloxacin Resistance in Pseudomonas aeruginosa and Facilitate Prediction of Resistance Phenotype from Genome Sequence Data.Antimicrobial agents and chemotherapy · 2021Article
- Dynamics of bacterial adaptation.Biochemical Society transactions · 2021Review
- The Effects of Sub-inhibitory Antibiotic Concentrations onFrontiers in microbiology · 2021Article
- The evolution and fate of diversity under hard and soft selection.Proceedings. Biological sciences · 2020Article
- Allelic polymorphism shapes community function in evolving Pseudomonas aeruginosa populations.The ISME journal · 2020Article
- Identifying the drivers of computationally detected correlated evolution among sites under antibiotic selection.Evolutionary applications · 2020Article
- Experimental Evolution of Innovation and Novelty.Trends in ecology & evolution · 2019Review
- Identifying genetic determinants of complex phenotypes from whole genome sequence data.BMC genomics · 2019Article
- Evolution of high-level resistance during low-level antibiotic exposure.Nature communications · 2018Article
- The emergence, maintenance, and demise of diversity in a spatially variable antibiotic regime.Evolution letters · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Antibiotic resistance evolves rapidly in response to drug selection, but it can also persist at appreciable levels even after the removal of the antibiotic. This suggests that many resistant strains can both be resistant and have high fitness in the absence of antibiotics. To explore the conditions under which high-fitness, resistant strains evolve and the genetic changes responsible, we used a combination of experimental evolution and whole-genome sequencing to track the acquisition of ciprofloxacin resistance in the opportunistic pathogen
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.