Evidence map›Paper›PMID 28744451›Full record

ArticleFrontiers in cellular and infection microbiology2017

Lipopolysaccharide Upregulated Intestinal Epithelial Cell Expression of Fn14 and Activation of Fn14 Signaling Amplify Intestinal TLR4-Mediated Inflammation.

Xuefeng Qi, Lijuan Qin, Ruijing Du, Yungang Chen, Mingzhu Lei, Meiyu Deng, Jingyu Wang

Open access · goldAbstract read
In one paragraph

Article in Frontiers in cellular and infection microbiology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
0.5field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 21 citations in OpenAlex.

  1. Article
  2. Article
  3. Impacts of F18Animals : an open access journal from MDPI · 2023
    Review
  4. Article
  5. Frontiers in nutrition · 2023
    Article
  6. Fn14 and TNFR2 as regulators of cytotoxic TNFR1 signaling.Frontiers in cell and developmental biology · 2023
    Review
  7. Article
  8. Review
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Xuefeng QiCollege of Veterinary Medicine, Northwest A&F UniversityYangling, China.
Lijuan QinCollege of Veterinary Medicine, Northwest A&F UniversityYangling, China.
Ruijing DuCollege of Veterinary Medicine, Northwest A&F UniversityYangling, China.
Yungang ChenCollege of Veterinary Medicine, Northwest A&F UniversityYangling, China.
Mingzhu LeiCollege of Veterinary Medicine, Northwest A&F UniversityYangling, China.
Meiyu DengCollege of Veterinary Medicine, Northwest A&F UniversityYangling, China.
Jingyu WangCollege of Veterinary Medicine, Northwest A&F UniversityYangling, China.
Northwest A&F University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

TLR4 in intestinal epithelial cells has been shown both inflammatory and homeostatic roles following binding of its cognate ligand lipopolysaccharide (LPS). TWEAK-Fn14 axis plays an important role in pathologies caused by excessive or abnormal inflammatory responses. This study aimed to evaluate potential cross-talk between TLR4 and TWEAK/Fn14 system in porcine small intestinal epithelial cells. Our

Indexed as

AnimalsApoptosisCytokine TWEAKEpithelial CellsEscherichia coliEscherichia coli InfectionsFemaleIntestinesLipopolysaccharidesMaleSignal TransductionSwineSwine DiseasesToll-Like Receptor 4TWEAK ReceptorCytokine TWEAKLipopolysaccharidesToll-Like Receptor 4TWEAK ReceptorFn14lipopolysaccharidesmall intestinal epithelial cellsTLR4TNF-αTWAEK

Identifiers

PMID28744451
PMCPMC5504244
OpenAlexW2735080368

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.