ArticleGastroenterology and hepatology from bed to bench2017
Oral squamous cell cancer protein-protein interaction network interpretation in comparison to esophageal adenocarcinoma.
Article in Gastroenterology and hepatology from bed to bench, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 28 citations in OpenAlex.
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- Exploring the Novel Computational Drug Target and Associated Key Pathways of Oral Cancer.Current issues in molecular biology · 2022Article
- Ontologies and Knowledge Graphs in Oncology Research.Cancers · 2022Review
- Using network pharmacology approaches to identify treatment mechanisms for codonopsis in esophageal cancer.International journal of clinical and experimental pathology · 2022Article
- Elucidating potential molecular signatures through host-microbe interactions for reactive arthritis and inflammatory bowel disease using combinatorial approach.Scientific reports · 2020Article
- The Challenges of OSCC Diagnosis: Salivary Cytokines as Potential Biomarkers.Journal of clinical medicine · 2020Review
- Differential MicroRNA Signatures in the Pathogenesis of Barrett's Esophagus.Clinical and translational gastroenterology · 2020Article
- The Impact of Proteomic Investigations on the Development and Improvement of Skin Laser Therapy: A Review Article.Journal of lasers in medical sciences · 2019Review
- Interaction Network Prediction and Analysis of Anorexia Nervosa.Iranian journal of child neurology · 2019Article
- Analysis of Laser Therapy Effects on Squamous Cell Carcinoma Patients: A System Biology Study.Journal of lasers in medical sciences · 2019Article
- Protein-Protein Interaction Network Analysis of Salivary Proteomic Data in Oral Cancer CasesAsian Pacific journal of cancer prevention : APJCP · 2018Article
- Nasopharyngeal Carcinoma Protein Interaction Mapping Analysis via Proteomic ApproachesAsian Pacific journal of cancer prevention : APJCP · 2018Article
- Protein-Protein Interaction Network Analysis Revealed a New Prospective of Posttraumatic Stress Disorder.Galen medical journal · 2018Article
- Metabolic analysis of acute appendicitis by using system biology approach.Gastroenterology and hepatology from bed to bench · 2018Article
- Protein-Protein Interaction Network Analysis for a Biomarker Panel Related to Human Esophageal AdenocarcinomaAsian Pacific journal of cancer prevention : APJCP · 2017Article
- Common and differential genetically pathways between ulcerative colitis and colon adenocarcinoma.Gastroenterology and hepatology from bed to bench · 2017Article
- Pancreatic adenocarcinoma protein-protein interaction network analysis.Gastroenterology and hepatology from bed to bench · 2017Article
- Network analysis of common genes related to esophageal, gastric, and colon cancers.Gastroenterology and hepatology from bed to bench · 2017Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimThe aim of this study is to present the oral Squamous Cell Cancer protein-protein interaction network interpretation in comparison to esophageal adenocarcinoma.
backgroundOral squamous cell cancer (OSCC) is a common disease worldwide, with poor prognosis and limited treatment. Thus, introducing molecular markers through network analysis can be helpful.
methodsSTRING database (DB) was applied for network construction through Cytoscape 3.4.0. Clue GO handled the gene annotation for the retrieved clusters. Eight proteins were indicated to be differential in the network constitution.
resultsThe centrality and clustering analysis indicate that TP53 plays an over-significant role in network integrity among eight most central proteins including TP53, AKT1, EGFR, MYC, JUN, CDH1, CCND1, and CTNNB1. The suggested biomarker set is very similar to the related biomarker panel of esophageal adenocarcinoma.
conclusionThe ontology analysis implies that the prominent proteins are involved in regulation of smooth muscle cell proliferation, regulation of fibroblast proliferation, and response to UV-A processes. In conclusion, these proteins and their associated biological processes may be more critical compared to other reported biomarkers for OSCC. Nevertheless, validation studies are required for confirming the pivotal role of potential candidates. Similar biomarker panel of this disease and esophagus adenocarcinoma is corresponded to the origin of the two malignancies.
Indexed as
Identifiers
28744358PMC5495899W2607690882What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.