ArticleToxicological research2017
Xylene Induces Oxidative Stress and Mitochondria Damage in Isolated Human Lymphocytes.
Article in Toxicological research, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 48 citations in OpenAlex.
- Royal jelly ameliorates behavioral deficit and hippocampal damage induced by inhalation exposure to xylene.Scientific reports · 2025Article
- Prospective study of oil spill cleanup-related exposure to volatile organic compounds and glycemic dysregulation.Environmental health : a global access science source · 2025Article
- Synthesis of Bio-Base Fluorescence Carbon Dots for Selective Detection of Tartrazine and Sunset Yellow in Food Samples.Journal of fluorescence · 2025Article
- Exposure to volatile organic compounds increases the risk of sarcopenia: Insights into association and mechanism.PloS one · 2025Article
- Altered oxidative stress and antioxidant biomarkers concentrations in pregnant individuals exposed to oil and gas sites in Northeastern British Columbia.Toxicological sciences : an official journal of the Society of Toxicology · 2024Article
- Guardians under Siege: Exploring Pollution's Effects on Human Immunity.International journal of molecular sciences · 2024Review
- Coniferyl ferulate alleviate xylene-caused hematopoietic stem and progenitor cell toxicity by Mgst2.Frontiers in pharmacology · 2024Article
- The association between oil spill cleanup-related total hydrocarbon exposure and diabetes.Environmental research · 2022Article
- Volatile organic compounds: A proinflammatory activator in autoimmune diseases.Frontiers in immunology · 2022Review
- Toxicological and Teratogenic Effect of Various Food Additives: An Updated Review.BioMed research international · 2022Review
- Dietary flaxseed's protective effects on body tissues of mice after oral exposure to xylene.Saudi journal of biological sciences · 2021Article
- Buckwheat, rooibos, and vitex extracts can mitigate adverse effects of xylene on ovarian cells in vitro.Environmental science and pollution research international · 2021Article
- Health examination results and work environment factors affecting urinary 8-hydroxy-2'-deoxyguanosine levels.Journal of occupational health · 2021Article
- Induced sputum metabolomic profiles and oxidative stress are associated with chronic obstructive pulmonary disease (COPD) severity: potential use for predictive, preventive, and personalized medicine.The EPMA journal · 2020Article
- Effect of tartrazine on digestive enzymatic activities: in vivo and in vitro studies.Toxicological research · 2020Article
- Toxicological Study and Genetic Basis of BTEX Susceptibility inFrontiers in genetics · 2020Article
- Shikonin Exerts Cytotoxic Effects in Human Colon Cancers by Inducing Apoptotic Cell Death via the Endoplasmic Reticulum and Mitochondria-Mediated Pathways.Biomolecules & therapeutics · 2019Article
- Embryotoxic and Teratogenic Effects of Tartrazine in Rats.Toxicological research · 2019Article
- Supply of Methionine During Late-Pregnancy Alters Fecal Microbiota and Metabolome in Neonatal Dairy Calves Without Changes in Daily Feed Intake.Frontiers in microbiology · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Xylene is a cyclic hydrocarbon and an environmental pollutant. It is also used in medical technology, paints, dyes, polishes and in many industries as a solvent; therefore, an understanding of the interaction between xylene and human lymphocytes is of significant interest. Biochemical assessment was used to demonstrate that exposure of lymphocytes to xylene induces cytotoxicity (at 6 hr), generates intracellular reactive oxygen species, collapse of mitochondrial membrane potential, lysosomal injury, lipid peroxidation and depletion of glutathione (at 3 hr). The findings show that xylene triggers oxidative stress and organelle damage in lymphocytes. The results of our study suggest that the use of antioxidant, mitochondrial and lysosomal protective agents can be helpful for individuals subject to chronic exposure to xylene.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.