ReviewFrontiers in endocrinology2017
Corticotropin-Releasing Hormone As the Homeostatic Rheostat of Feto-Maternal Symbiosis and Developmental Programming
Review in Frontiers in endocrinology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed, 35 citations in OpenAlex.
- The cervicovaginal gut microbiota axis as a key determinant of systemic physiology.Gut microbes · 2026Review
- Glucocorticoid Receptor Signaling: Multilevel Organization, Roles in Fetal Development, and Postnatal Outcomes.International journal of molecular sciences · 2026Review
- The role of perinatal perceived stress in the setting of adverse childhood experience and perinatal anxiety and depressive symptoms.BMC psychology · 2025Article
- Stress-induced developmental plasticity and spontaneous preterm birth: A justice-oriented eco-evo-devo review.European journal of obstetrics & gynecology and reproductive biology: X · 2025Review
- Psychosocial stress and associations with inflammation in mid-gestation maternal, fetal, and placental tissue.Reproductive toxicology (Elmsford, N.Y.) · 2025Article
- Associations among PMEnvironmental research communications · 2025Article
- Effects of reproductive experience on cost-benefit decision making in female rats.Frontiers in behavioral neuroscience · 2024Article
- Review
- Metabolomic profiling of intrauterine growth-restricted preterm infants: a matched case-control study.Pediatric research · 2023Article
- Childbirth fear in the USA during the COVID-19 pandemic: key predictors and associated birth outcomes.Evolution, medicine, and public health · 2023Article
- Neonatal breast-suckling skills in the context of lactation and peripartum hormonal changes and additional factors-a pilot study.International breastfeeding journal · 2022Article
- Pregnancy anxiety, placental corticotropin-releasing hormone and length of gestation.Biological psychology · 2022Article
- Influence of geographic conditions on body length of male newborns in Kyrgyzstan.International journal of biometeorology · 2021Article
- Effect of Excessive Body Weight and Emotional Disorders on the Course of Pregnancy and Well-Being of a Newborn before and during COVID-19 Pandemic.Journal of clinical medicine · 2021Article
- Placental CRH as a Signal of Pregnancy Adversity and Impact on Fetal Neurodevelopment.Frontiers in endocrinology · 2021Review
- Prenatal Maternal Objective and Subjective Stress Exposures and Rapid Infant Weight Gain.The Journal of pediatrics · 2020Observational
- Fetal Adrenal Gland Volume a Novel Predictor of Onset of Labor.Journal of obstetrics and gynaecology of India · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A balanced interaction between the homeostatic mechanisms of mother and the developing organism during pregnancy and in early neonatal life is essential in order to ensure optimal fetal development, ability to respond to various external and internal challenges, protection from adverse programming, and safeguard maternal care availability after parturition. In the majority of pregnancies, this relationship is highly effective resulting in successful outcomes. However, in a number of pathological settings, perturbations of the maternal homeostasis disrupt this symbiosis and initiate adaptive responses with unpredictable outcomes for the fetus or even the neonate. This may lead to development of pathological phenotypes arising from developmental reprogramming involving interaction of genetic, epigenetic, and environmental-driven pathways, sometimes with acute consequences (e.g., growth impairment) and sometimes delayed (e.g., enhanced susceptibility to disease) that last well into adulthood. Most of these adaptive mechanisms are activated and controlled by hormones of the hypothalamo-pituitary adrenal axis under the influence of placental steroid and peptide hormones. In particular, the hypothalamic peptide corticotropin-releasing hormone (CRH) plays a key role in feto-maternal communication by orchestrating and integrating a series of neuroendocrine, immune, metabolic, and behavioral responses. CRH also regulates neural networks involved in maternal behavior and this determines efficiency of maternal care and neonate interactions. This review will summarize our current understanding of CRH actions during the perinatal period, focusing on the physiological roles for both mother and offspring and also how external challenges can alter CRH actions and potentially impact on fetus/neonate health.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.