ArticleOncoTargets and therapy2017
Evaluation of
Article in OncoTargets and therapy, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
12 citing papers in PubMed, 23 citations in OpenAlex.
- Network-based analysis reveals potential microRNA regulation of oncogenic pathways in SOX10-depleted uveal melanoma.Cellular and molecular life sciences : CMLS · 2026Article
- Exploring p53 isoforms: unraveling heterogeneous p53 tumor suppressor functionality in uveal melanoma.Cell death discovery · 2025Article
- Exploring recent advances in signaling pathways and hallmarks of uveal melanoma: a comprehensive review.Exploration of targeted anti-tumor therapy · 2025Review
- Exploring the use of p53 protein expression as an indicator of oesophageal cancer severity from a high incidence rural area of Africa.African health sciences · 2022Article
- Antiproliferative and apoptotic potential of Glycyrrhizin against HPV16+ Caski cervical cancer cells: A plausible association with downreguation of HPV E6 and E7 oncogenes and Notch signaling pathway.Saudi journal of biological sciences · 2022Article
- Exploring the use of p53 protein expression as an indicator of oesophageal cancer severity from a high incidence rural area of Africa.African health sciences · 2022Article
- A lepidic gene signature predicts patient prognosis and sensitivity to immunotherapy in lung adenocarcinoma.Genome medicine · 2022Article
- Implication of ARID1A Undercurrents and PDL1, TP53 Overexpression in Advanced Gastric Cancer.Pathology oncology research : POR · 2021Article
- Molecular characteristics of uveal melanoma and intraocular tumors.Oncology letters · 2021Review
- p53 protein expression affected by TP53 polymorphism is associated with the biological behavior and prognosis of low rectal cancer.Oncology letters · 2019Article
- Germline mutation in the TP53 gene in uveal melanoma.Scientific reports · 2018Article
- Locally advanced choroidal melanoma with favorable molecular prognosis - case report.Romanian journal of morphology and embryology = Revue roumaine de morphologie et embryologieArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveThe objective of this study was to evaluate the correlation between the expression of MATERIALS AND
methodsReal-time polymerase chain reaction (RT-PCR) test and Western blot were used to detect the expression of p53 in C918, MUM-2B, and D78 cell lines at the levels of messenger RNA (mRNA) and protein. Immunohistochemistry staining was done in the tissues of 68 patients, which were diagnosed with uveal melanoma. Furthermore, the effects of p53 protein on the invasion abilities of both the cell lines were studied by transinfection of p53 small interfering RNA. The clinical and prognostic data regarding the effect of p53 protein on the patient's prognosis were calculated and further analyzed by Kaplan-Meier univariate analysis method.
resultsThe results of RT-PCR and Western blot revealed that p53 mRNAs were highly expressed in C918 and MUM-2B cells. The high expression rate of p53 among the 88 uveal melanoma tissues was 77.27%. Transinfection of p53 serine could inhibit the expression of p53 in uveal melanoma and the invasion ability of the cells. This study found that the high expression of p53 and the prognosis of uveal melanoma patients were statistically correlated.
conclusionThe expression of p53 protein in uveal melanoma was unusual and was associated with the invasion ability of uveal melanoma. This indicates that the highest expression of p53 protein indicates worse prognosis of uveal melanoma patients.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.