Evidence map›Paper›PMID 28744119›Full record

ArticleInternational journal of nanomedicine2017

Spatiotemporal delivery of nanoformulated liraglutide for cardiac regeneration after myocardial infarction.

Quan Qi, Lei Lu, Haiqing Li, Zhize Yuan, Gaoxian Chen, Miao Lin, Zhengwen Ruan, Xiaofeng Ye, Zeyu Xiao, Qiang Zhao

Open access · goldAbstract read
In one paragraph

Article in International journal of nanomedicine, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
6.0field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 41 citations in OpenAlex.

  1. Review
  2. Review
  3. Review
  4. Review
  5. Nanomedicines for cardiovascular disease.Nature cardiovascular research · 2023
    Review
  6. Article
  7. Review
  8. Review
  9. Review
  10. Article
  11. Nanoparticle-Mediated Drug Delivery for Treatment of Ischemic Heart Disease.Frontiers in bioengineering and biotechnology · 2020
    Review
  12. Article
  13. Liraglutide Increases VEGF ExpressionFrontiers in pharmacology · 2019
    Article
  14. Review
  15. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 3 countries.

Quan QiDepartment of Cardiac Surgery, Rui Jin Hospital.
Lei LuDepartment of Pharmacology, Institute of Medical Sciences.
Haiqing LiDepartment of Cardiac Surgery, Rui Jin Hospital.
Zhize YuanDepartment of Cardiac Surgery, Rui Jin Hospital.
Gaoxian ChenDepartment of Pharmacology, Institute of Medical Sciences.
Miao LinDepartment of Pharmacology, Institute of Medical Sciences.
Zhengwen RuanDepartment of Cardiology, Yuyao People's Hospital, Yuyao, Zhejiang.
Xiaofeng YeDepartment of Cardiac Surgery, Rui Jin Hospital.
Zeyu XiaoDepartment of Pharmacology, Institute of Medical Sciences.
Qiang ZhaoDepartment of Cardiac Surgery, Rui Jin Hospital.
Wenzhou Medical University · CNShanghai Jiao Tong University · CNYuxian People's Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The local, intramyocardial injection of proteins into the infarcted heart is an attractive option to initiate cardiac regeneration after myocardial infarction (MI). Liraglutide, which was developed as a treatment for type 2 diabetes, has been implicated as one of the most promising protein candidates in cardiac regeneration. A significant challenge to the therapeutic use of this protein is its short half-life in vivo. In this study, we evaluated the therapeutic effects and long-term retention of liraglutide loaded in poly(lactic-

Indexed as

AnimalsApoptosisDrug Delivery SystemsHeartLiraglutideMaleMyocardial InfarctionMyocytes, CardiacNanoparticlesPolyethylene GlycolsPolyglactin 910Rats, Sprague-DawleyRegenerationLiraglutidePolyethylene GlycolsPolyglactin 910poly(lactic-glycolic acid)-poly(ethyleneglycol) copolymercardiac regenerationnanoformulated liraglutidespatiotemporal delivery

Identifiers

PMID28744119
PMCPMC5511023
OpenAlexW2731231063

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.