ArticleInternational journal of chronic obstructive pulmonary disease2017
Alteration of the irisin-brain-derived neurotrophic factor axis contributes to disturbance of mood in COPD patients.
Article in International journal of chronic obstructive pulmonary disease, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 37 citations in OpenAlex.
- Baseline Plasma BDNF Levelsare Associated with Antianhedonic Effects of Repeated-Dose Intravenous Ketamine in Major Depressive Disorder.Current neuropharmacology · 2023Trial
- Irisin maintains ER homeostasis and activates AMPK via integrin αVβ5 to attenuate CSE + LPS-induced emphysema and inflammation.Respiratory research · 2026Article
- Therapeutic Potential of Irisin in Neurodegenerative Diseases.International journal of molecular sciences · 2025Review
- The Influence of Irisin on Selected Organs-The Liver, Kidneys, and Lungs: The Role of Physical Exercise.Cells · 2025Review
- Emotional state in patients after COVID-19 in relation to comprehensive rehabilitation, Brain-Derived neurotrophic factor, Irisin levels, and selected clinical factors.Scientific reports · 2025Article
- Potential role of FNDC5 in exercise-induced improvement of cognitive function.Journal of Zhejiang University. Science. B · 2025Review
- Smoking-Dependent Association of Serum Brain-Derived Neurotrophic Factor with Pulmonary Function Parameters in Chronic Obstructive Pulmonary Disease.Medicina (Kaunas, Lithuania) · 2024Article
- Study on Potential Differentially Expressed Genes in Idiopathic Pulmonary Fibrosis by Bioinformatics and Next-Generation Sequencing Data Analysis.Biomedicines · 2023Article
- A 21-Day Individual Rehabilitation Exercise Training Program Changes Irisin, Chemerin, and BDNF Levels in Patients after Hip or Knee Replacement Surgery.Journal of clinical medicine · 2023Article
- The Potential Roles of Myokines in Adipose Tissue Metabolism with Exercise and Cold Exposure.International journal of molecular sciences · 2022Review
- The Changes of Irisin and Inflammatory Cytokines in the Age-Related Macular Degeneration and Retinal Vein Occlusion.Frontiers in endocrinology · 2022Article
- Disturbances in branched-chain amino acid profile and poor daily functioning in mildly depressed chronic obstructive pulmonary disease patients.BMC pulmonary medicine · 2021Article
- Irisin Acts via the PGC-1α and BDNF Pathway to Improve Depression-like Behavior.Clinical nutrition research · 2021Review
- Effect of BDNF on airway inflammation in a rat model of COPD.Experimental and therapeutic medicine · 2021Article
- Basal myokine levels are associated with quality of life and depressed mood in older adults.Psychophysiology · 2021Article
- Altered irisin/BDNF axis parallels excessive daytime sleepiness in obstructive sleep apnea patients.Respiratory research · 2019Article
- Roles of myokines in exercise-induced improvement of neuropsychiatric function.Pflugers Archiv : European journal of physiology · 2019Review
- The Role of PGC-1α/UCP2 Signaling in the Beneficial Effects of Physical Exercise on the Brain.Frontiers in neuroscience · 2019Review
- The Neuroprotective Effects of Exercise: Maintaining a Healthy Brain Throughout Aging.Brain plasticity (Amsterdam, Netherlands) · 2018Review
- Molecular and Functional Interaction of the Myokine Irisin with Physical Exercise and Alzheimer's Disease.Molecules (Basel, Switzerland) · 2018Review
Corrections and comments
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Authors and funding
10 authors at 4 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
COPD is accompanied by limited physical activity, worse quality of life, and increased prevalence of depression. A possible link between COPD and depression may be irisin, a myokine, expression of which in the skeletal muscle and brain positively correlates with physical activity. Irisin enhances the synthesis of brain-derived neurotrophic factor (BDNF), a neurotrophin involved in reward-related processes. Thus, we hypothesized that mood disturbances accompanying COPD are reflected by the changes in the irisin-BDNF axis. Case history, routine laboratory parameters, serum irisin and BDNF levels, pulmonary function, and disease-specific quality of life, measured by St George's Respiratory Questionnaire (SGRQ), were determined in a cohort of COPD patients (n=74). Simple and then multiple linear regression were used to evaluate the data. We found that mood disturbances are associated with lower serum irisin levels (SGRQ's Impacts score and reciprocal of irisin showed a strong positive association; β: 419.97; 95% confidence interval [CI]: 204.31, 635.63;
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.