Evidence map›Paper›PMID 28744067›Full record

ArticleMediators of inflammation2017

Helminth Products Potently Modulate Experimental Autoimmune Encephalomyelitis by Downregulating Neuroinflammation and Promoting a Suppressive Microenvironment.

Alberto N Peón, Yadira Ledesma-Soto, Jonadab E Olguín, Marcel Bautista-Donis, Edda Sciutto, Luis I Terrazas

Open access · goldAbstract read
In one paragraph

Article in Mediators of inflammation, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
2.0field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 24 citations in OpenAlex.

  1. Article
  2. Parasitology · 2022
    Article
  3. Article
  4. Review
  5. Article
  6. Review
  7. Review
  8. The Helminth ParasiteFrontiers in immunology · 2020
    Article
  9. Review
  10. Journal of immunology research · 2019
    Article
  11. Review
  12. Review
  13. Novel Therapeutics for Multiple Sclerosis Designed by Parasitic Worms.International journal of molecular sciences · 2017
    Review
  14. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Alberto N PeónUnidad de Biomedicina, Facultad de Estudios Superiores Iztacala (FES-I), Universidad Nacional Autónoma de Mexico (UNAM), MEX, Mexico.ORCID 0000-0001-6951-2248
Yadira Ledesma-SotoUnidad de Biomedicina, Facultad de Estudios Superiores Iztacala (FES-I), Universidad Nacional Autónoma de Mexico (UNAM), MEX, Mexico.
Jonadab E OlguínUnidad de Biomedicina, Facultad de Estudios Superiores Iztacala (FES-I), Universidad Nacional Autónoma de Mexico (UNAM), MEX, Mexico.
Marcel Bautista-DonisDepartamento de Inmunología, Instituto de Investigaciones Biomédicas, UNAM, Mexico City, Mexico.
Edda SciuttoDepartamento de Inmunología, Instituto de Investigaciones Biomédicas, UNAM, Mexico City, Mexico.ORCID 0000-0001-5608-5355
Luis I TerrazasUnidad de Biomedicina, Facultad de Estudios Superiores Iztacala (FES-I), Universidad Nacional Autónoma de Mexico (UNAM), MEX, Mexico.ORCID 0000-0003-1635-9467
Universidad Nacional Autónoma de México · MX

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A negative correlation between the geographical distribution of autoimmune diseases and helminth infections has been largely associated in the last few years with a possible role for such type of parasites in the regulation of inflammatory diseases, suggesting new pathways for drug development. However, few helminth-derived immunomodulators have been tested in experimental autoimmune encephalomyelitis (EAE), an animal model of the human disease multiple sclerosis (MS). The immunomodulatory activities of

Indexed as

AnimalsCell ProliferationCentral Nervous SystemEncephalomyelitis, Autoimmune, ExperimentalEnzyme-Linked Immunosorbent AssayFemaleHelminthsImmunologic FactorsMiceMice, Inbred BALB CMultiple SclerosisTaeniaTh17 CellsTh1 CellsImmunologic Factors

Identifiers

PMID28744067
PMCPMC5506484
OpenAlexW2731095606

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.