ArticleScientific reports2017
A sensitive acupuncture needle microsensor for real-time monitoring of nitric oxide in acupoints of rats.
Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed.
- Research and application advances in real-time single-cell functional analysis.Discover nano · 2026Review
- Engineering graphene oxide interfaces for electrochemical biosensing of biomolecules, cells, and organoids.Nano convergence · 2026Review
- Stimulation of High-Conductivity Points in Human Skin Reduces Biotin Levels to Modulate Intracellular Metabolism and Local Energy Production.Health science reports · 2025Article
- Chinese acupoint therapies in cancer pain management: research advances and future perspectives.Pain management · 2025Review
- Biomaterials for neuroengineering: applications and challenges.Regenerative biomaterials · 2025Review
- Review
- Implantable Electrochemical Microsensors for In Vivo Monitoring of Animal Physiological Information.Nano-micro letters · 2023Review
- Graphene nanocomposites for real-time electrochemical sensing of nitric oxide in biological systems.Applied physics reviews · 2023Article
- Article
- Delivery of Nitric Oxide in the Cardiovascular System: Implications for Clinical Diagnosis and Therapy.International journal of molecular sciences · 2021Review
- Azaporphyrins Embedded on Carbon-Based Nanomaterials for Potential Use in Electrochemical Sensing-A Review.Nanomaterials (Basel, Switzerland) · 2021Review
- Noble metal sensitized invasive porous bioelectrodes: advanced medical device for enhanced neuronal activity and chronic alcohol treatment.RSC advances · 2020Article
- Microneedles Drug Delivery Systems for Treatment of Cancer: A Recent Update.Pharmaceutics · 2020Review
- Article
- Microneedles for transdermal diagnostics: Recent advances and new horizons.Biomaterials · 2020Review
- Understanding Acupoint Sensitization: A Narrative Review on Phenomena, Potential Mechanism, and Clinical Application.Evidence-based complementary and alternative medicine : eCAM · 2019Review
- Functionalized microneedles for continuous glucose monitoring.Nano convergence · 2018Review
- Nitric oxide detection methodsMedical gas researchReview
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Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This study reports an acupuncture needle modified with an iron-porphyrin functionalized graphene composite (FGPC) for real-time monitoring of nitric oxide (NO) release in acupoints of rats. A gold film was first deposited to the needle surface to enhance the conductivity. The FGPC was prepared via hydrothermal synthesis, and subsequently applied to the tip surface of acupuncture needle by electrochemical deposition method. The functionalized needle enabled a specific and sensitive detection of NO based on the favorably catalytic properties of iron-porphyrin and the excellent conductivity of graphene. Amperometric data showed that the needle achieved not only a low detection limit down to 3.2 nM in PBS solution, but also a satisfactory selectivity. Interestingly, the functionalized needle could be inserted into the acupoints of rats for real-time monitoring of NO in vivo. It was found that a remarkable response to NO was respectively obtained in different acupoints when stimulated by
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