ArticleScientific reports2017
Pupil adaptation corresponds to quantitative measures of autism traits in children.
Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 38 citations in OpenAlex.
- Analysis of the Pupillary Light Reflex Response Against Light Stimuli for Autism Screening in Children.Journal of autism and developmental disorders · 2026Article
- Investigation of the functional interaction between problematic behaviors, social interaction, and attentional orienting.BMC psychology · 2026Article
- The Pupil-Brain System at Rest: Spontaneous Pupil Fluctuations as Markers of Neuromodulatory and Network Dynamics.Psychophysiology · 2026Review
- Pupil responses to social stimuli are associated with adaptive behaviors across the first 24 months of life.Journal of neurodevelopmental disorders · 2025Article
- Dysregulation of heterochromatin caused by genomic structural variants may be central to autism spectrum disorder.Frontiers in molecular neuroscience · 2025Article
- Interest paradigm for early identification of autism spectrum disorder: an analysis from electroencephalography combined with eye tracking.Frontiers in neuroscience · 2024Article
- Assessment of autonomic symptom scales in patients with neurodevelopmental diagnoses using electronic health record data.Research in autism spectrum disorders · 2023Article
- Identification of diagnostic markers for ASD: a restrictive interest analysis based on EEG combined with eye tracking.Frontiers in neuroscience · 2023Article
- Dynamic eye avoidance patterns in the high autistic traits group: An eye-tracking study.Frontiers in psychiatry · 2023Article
- Associations between the pupil light reflex and the broader autism phenotype in children and adults.Frontiers in human neuroscience · 2022Article
- An auditory processing advantage enables communication in less complex social settings: Signs of an extreme female brain in children and adolescents being assessed for Autism Spectrum Disorders.Frontiers in psychology · 2022Article
- Slower Peak Pupillary Response to Emotional Faces in Parents of Autistic Individuals.Frontiers in psychology · 2022Article
- Eye pupil - a window into central autonomic regulation via emotional/cognitive processing.Physiological research · 2021Review
- Resting and Functional Pupil Response Metrics Indicate Features of Reward Sensitivity and ASD in Children.Journal of autism and developmental disorders · 2021Article
- The future of quantitative pupillometry in health and disease.Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2020Article
- A longitudinal study of pupillary light reflex in 6- to 24-month children.Scientific reports · 2020Article
- Disease Classification Based on Eye Movement Features With Decision Tree and Random Forest.Frontiers in neuroscience · 2020Article
- Brief Report: Pupillometry, Visual Perception, and ASD Features in a Task-Switching Paradigm.Journal of autism and developmental disorders · 2019Article
- Brief Report: Visual Perception, Task-Induced Pupil Response Trajectories and ASD Features in Children.Journal of autism and developmental disorders · 2019Article
- Updated View on the Relation of the Pineal Gland to Autism Spectrum Disorders.Frontiers in endocrinology · 2019Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The pupil is known to reflect a range of psychological and physiological variables, including cognitive effort, arousal, attention, and even learning. Within autism spectrum disorder (ASD), some work has used pupil physiology to successfully classify patients with or without autism. As we have come to understand the heterogeneity of ASD and other neurodevelopmental disorders, the relationship between quantitative traits and physiological markers has become increasingly more important, as this may lead us closer to the underlying biological basis for atypical responses and behaviors. We implemented a novel paradigm designed to capture patterns of pupil adaptation during sustained periods of dark and light conditions in a pediatric sample that varied in intellectual ability and clinical features. We also investigate the relationship between pupil metrics derived from this novel task and quantitative behavioral traits associated with the autism phenotype. We show that pupil metrics of constriction and dilation are distinct from baseline metrics. Pupil dilation metrics correlate with individual differences measured by the Social Responsiveness Scale (SRS), a quantitative measure of autism traits. These results suggest that using a novel, yet simple, paradigm can result in meaningful pupil metrics that correlate with individual differences in autism traits, as measured by the SRS.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.