Evidence map›Paper›PMID 28743915›Full record

ArticleScientific reports2017

Platelet behaviour on von Willebrand Factor changes in pregnancy: Consequences of haemodilution and intrinsic changes in platelet function.

Jonathan Cowman, Sieglinde Müllers, Eimear Dunne, Adam Ralph, Antonio J Ricco, Fergal D Malone, Dermot Kenny

Open access · goldAbstract read
In one paragraph

Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.3field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 14 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Article
  6. Observational
  7. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Jonathan CowmanMolecular and Cellular Therapeutics, Royal College of Surgeons in Ireland, Dublin, Ireland.
Sieglinde MüllersObstetrics and Gynecology, Royal College of Surgeons in Ireland, Dublin, Ireland.
Eimear DunneMolecular and Cellular Therapeutics, Royal College of Surgeons in Ireland, Dublin, Ireland.ORCID 0000-0001-9862-1398
Adam RalphIrish Centre for High-end Computing, National University, Ireland, Galway, Ireland.
Antonio J RiccoMolecular and Cellular Therapeutics, Royal College of Surgeons in Ireland, Dublin, Ireland.
Fergal D MaloneObstetrics and Gynecology, Royal College of Surgeons in Ireland, Dublin, Ireland.
Dermot KennyMolecular and Cellular Therapeutics, Royal College of Surgeons in Ireland, Dublin, Ireland. dkenny@rcsi.ie.
Royal College of Surgeons in Ireland · IEIrish Centre for High-End Computing · IE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Platelet function in pregnancy is poorly understood. Previous studies of platelet function in pregnancy have used non-physiological assays of platelet function with conflicting results. This study using a physiological assay of platelet function investigated platelet interactions with von Willebrand Factor (VWF) in blood from healthy pregnant women and healthy non-pregnant controls. Blood samples (200 µl) from third-trimester pregnancies (n = 21) and non-pregnant controls (n = 21) were perfused through custom-made parallel-plate flow chambers coated with VWF under arterial shear (1,500 s

Indexed as

AdultBlood PlateletsFemaleHealthy VolunteersHemodilutionHemostasisHumansPregnancyPregnancy Trimester, ThirdShear Strengthvon Willebrand FactorYoung Adultvon Willebrand Factor

Identifiers

PMID28743915
PMCPMC5527092
OpenAlexW2738481931

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.