Evidence map›Paper›PMID 28743913›Full record

ArticleScientific reports2017

MicroRNA-200b regulates distal airway development by maintaining epithelial integrity.

Naghmeh Khoshgoo, Robin Visser, Landon Falk, Chelsea A Day, Dustin Ameis, Barbara M Iwasiow, Fuqin Zhu, Arzu Öztürk, Sujata Basu, Molly Pind and 7 more

Open access · goldAbstract read
In one paragraph

Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
4.2field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 46 citations in OpenAlex.

  1. Article
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  9. Molecular therapy. Nucleic acids · 2023
    Article
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  11. Article
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  14. Article
  15. Article
  16. Article
  17. miRNAs in Lung Development and Diseases.International journal of molecular sciences · 2020
    Review
  18. Review
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 4 institutions in 1 country.

Naghmeh KhoshgooBiology of Breathing Group, The Children's Hospital Research Institute of Manitoba, Winnipeg, Manitoba, Canada.
Robin VisserBiology of Breathing Group, The Children's Hospital Research Institute of Manitoba, Winnipeg, Manitoba, Canada.
Landon FalkBiology of Breathing Group, The Children's Hospital Research Institute of Manitoba, Winnipeg, Manitoba, Canada.
Chelsea A DayBiology of Breathing Group, The Children's Hospital Research Institute of Manitoba, Winnipeg, Manitoba, Canada.
Dustin AmeisBiology of Breathing Group, The Children's Hospital Research Institute of Manitoba, Winnipeg, Manitoba, Canada.
Barbara M IwasiowBiology of Breathing Group, The Children's Hospital Research Institute of Manitoba, Winnipeg, Manitoba, Canada.
Fuqin ZhuBiology of Breathing Group, The Children's Hospital Research Institute of Manitoba, Winnipeg, Manitoba, Canada.
Arzu ÖztürkResearch Institute of Oncology and Hematology, CancerCare Manitoba, Winnipeg, Manitoba, Canada.
Sujata BasuBiology of Breathing Group, The Children's Hospital Research Institute of Manitoba, Winnipeg, Manitoba, Canada.
Molly PindResearch Institute of Oncology and Hematology, CancerCare Manitoba, Winnipeg, Manitoba, Canada.
Agnes FresnosaResearch Institute of Oncology and Hematology, CancerCare Manitoba, Winnipeg, Manitoba, Canada.
Mike JacksonSmall Animal and Materials Imaging Core Facility, University of Manitoba, Winnipeg, Manitoba, Canada.
Vinaya Kumar SiragamBiology of Breathing Group, The Children's Hospital Research Institute of Manitoba, Winnipeg, Manitoba, Canada.
Gerald StelmackBiology of Breathing Group, The Children's Hospital Research Institute of Manitoba, Winnipeg, Manitoba, Canada.
Geoffrey G HicksResearch Institute of Oncology and Hematology, CancerCare Manitoba, Winnipeg, Manitoba, Canada.
Andrew J HalaykoBiology of Breathing Group, The Children's Hospital Research Institute of Manitoba, Winnipeg, Manitoba, Canada.
Richard KeijzerBiology of Breathing Group, The Children's Hospital Research Institute of Manitoba, Winnipeg, Manitoba, Canada. richardkeijzer@gmail.com.ORCID 0000-0002-0108-3157
Children's Hospital Research Institute of Manitoba · CACancerCare Manitoba · CAResearch Manitoba · CAUniversity of Manitoba · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

miR-200b plays a role in epithelial-to-mesenchymal transition (EMT) in cancer. We recently reported abnormal expression of miR-200b in the context of human pulmonary hypoplasia in congenital diaphragmatic hernia (CDH). Smaller lung size, a lower number of airway generations, and a thicker mesenchyme characterize pulmonary hypoplasia in CDH. The aim of this study was to define the role of miR-200b during lung development. Here we show that miR-200b

Indexed as

Up-RegulationAnimalsEpithelial CellsGene Expression ProfilingGene Expression Regulation, DevelopmentalGene Knockout TechniquesGene OntologyGene Regulatory NetworksHernias, Diaphragmatic, CongenitalHumansLungMiceMicroRNAsRespiratory Function TestsSequence Analysis, RNAMicroRNAsMIRN200 microRNA, humanMirn200 microRNA, mouse

Identifiers

PMID28743913
PMCPMC5526907
OpenAlexW2737866358

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.