ArticleScientific reports2017
Primitive erythrocytes are generated from hemogenic endothelial cells.
Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 42 citations in OpenAlex.
- Hematopoietic stem cell-independent and -dependent hematopoiesis: new insights and lineage-tracing methods.Experimental hematology · 2026Review
- Bloodhounds chasing the origin of blood cells.Trends in cell biology · 2025Review
- Impaired primitive erythropoiesis and defective vascular development in Trim71-KO embryos.Life science alliance · 2025Article
- New insights into the endothelial origin of hematopoietic system inspired by "TIF" approaches.Blood science (Baltimore, Md.) · 2024Review
- CD32 captures committed haemogenic endothelial cells during human embryonic development.Nature cell biology · 2024Article
- Linking Benzene, in Utero Carcinogenicity and Fetal Hematopoietic Stem Cell Niches: A Mechanistic Review.International journal of molecular sciences · 2023Review
- Review
- Review
- Modeling human yolk sac hematopoiesis with pluripotent stem cells.The Journal of experimental medicine · 2022Article
- Pyruvate metabolism guides definitive lineage specification during hematopoietic emergence.EMBO reports · 2022Article
- Scalable in vitro production of defined mouse erythroblasts.PloS one · 2022Article
- FOXO1 regulates pentose phosphate pathway-mediated induction of developmental erythropoiesis.Frontiers in cell and developmental biology · 2022Article
- Ezh2 is essential for the generation of functional yolk sac derived erythro-myeloid progenitors.Nature communications · 2021Article
- Germline competent mesoderm: the substrate for vertebrate germline and somatic stem cells?Biology open · 2021Article
- Glutamine metabolism regulates endothelial to hematopoietic transition and hematopoietic lineage specification.Scientific reports · 2021Article
- Contributions of Embryonic HSC-Independent Hematopoiesis to Organogenesis and the Adult Hematopoietic System.Frontiers in cell and developmental biology · 2021Review
- Cellular Basis of Embryonic Hematopoiesis and Its Implications in Prenatal Erythropoiesis.International journal of molecular sciences · 2020Review
- Yolk sac hematopoiesis: does it contribute to the adult hematopoietic system?Cellular and molecular life sciences : CMLS · 2020Review
- Blood making: learning what to put into the dish.F1000Research · 2020Review
- Transcriptional control of blood cell emergence.FEBS letters · 2019Review
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
Primitive erythroblasts are the first blood cells generated during embryonic hematopoiesis. Tracking their emergence both in vivo and in vitro has remained challenging due to the lack of specific cell surface markers. To selectively investigate primitive erythropoiesis, we have engineered a new transgenic embryonic stem (ES) cell line, where eGFP expression is driven by the regulatory sequences of the embryonic βH1 hemoglobin gene expressed specifically in primitive erythroid cells. Using this ES cell line, we observed that the first primitive erythroblasts are detected in vitro around day 1.5 of blast colony differentiation, within the cell population positive for the early hematopoietic progenitor marker CD41. Moreover, we establish that these eGFP
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.