ArticleScientific reports2017
Nicotinamide mononucleotide and related metabolites induce disease resistance against fungal phytopathogens in Arabidopsis and barley.
Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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21 citing papers in PubMed, 35 citations in OpenAlex.
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- Cerebral Ischemia-Reperfusion Injury: Unraveling the Mitophagy-Oxidative Stress Axis for Neuroprotective Strategies.International journal of molecular sciences · 2026Review
- Constant Illumination Boosts Rice Immunity via the Nicotinamide Mononucleotide Signaling Pathway: A Mechanistic Exploration.Rice (New York, N.Y.) · 2026Article
- Biogeography influences plant-microbe interactions and natural soil suppressiveness to black root rot disease of tobacco.Genome biology · 2025Article
- An agroecological structure model of compost-soil-plant interactions for sustainable organic farming.ISME communications · 2023Article
- Integrated transcriptome and metabolome analysis unveil the response mechanism in wild rice (Frontiers in genetics · 2023Article
- Proteomic Profiling of Plant and Pathogen Interaction on the Leaf Epidermis.International journal of molecular sciences · 2022Article
- Combined transcriptome and metabolome analysis of Nerium indicum L. elaborates the key pathways that are activated in response to witches' broom disease.BMC plant biology · 2022Article
- Metabolomics Insights into Chemical Convergence inMetabolites · 2021Article
- Overexpression of nicotinamidase 3 (NIC3) gene and the exogenous application of nicotinic acid (NA) enhance drought tolerance and increase biomass in Arabidopsis.Plant molecular biology · 2021Article
- An update on redox signals in plant responses to biotic and abiotic stress crosstalk: insights from cadmium and fungal pathogen interactions.Journal of experimental botany · 2021Review
- Genome-wide shifts in histone modifications at early stage of rice infection with Meloidogyne graminicola.Molecular plant pathology · 2021Article
- Nicotinamide Effectively Suppresses Fusarium Head Blight in Wheat Plants.International journal of molecular sciences · 2021Article
- Nicotinamide Mononucleotide Potentiates Resistance to Biotrophic Invasion of Fungal Pathogens in Barley.International journal of molecular sciences · 2021Article
- Potential of nicotinamide adenine dinucleotide (NAD) for management of root-knot nematode in tomato.Journal of nematology · 2021Article
- Plant Responses Underlying Timely Specialized Metabolites Induction ofFrontiers in plant science · 2021Article
- MicroRNA miR-1002 Enhances NMNAT-Mediated Stress Response by Modulating Alternative Splicing.iScience · 2019Article
- A role for 3'-O-β-D-ribofuranosyladenosine in altering plant immunity.Phytochemistry · 2019Article
- Nicotinamide adenine dinucleotide induced resistance against root-knot nematodeJournal of nematology · 2019Article
- The possible roles ofPlant biotechnology (Tokyo, Japan) · 2018Article
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7 authors at 4 institutions in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
Nicotinamide mononucleotide (NMN), a precursor of nicotinamide adenine dinucleotide (NAD), is known to act as a functional molecule in animals, whereas its function in plants is largely unknown. In this study, we found that NMN accumulated in barley cultivars resistant to phytopathogenic fungal Fusarium species. Although NMN does not possess antifungal activity, pretreatment with NMN and related metabolites enhanced disease resistance to Fusarium graminearum in Arabidopsis leaves and flowers and in barley spikes. The NMN-induced Fusarium resistance was accompanied by activation of the salicylic acid-mediated signalling pathway and repression of the jasmonic acid/ethylene-dependent signalling pathways in Arabidopsis. Since NMN-induced disease resistance was also observed in the SA-deficient sid2 mutant, an SA-independent signalling pathway also regulated the enhanced resistance induced by NMN. Compared with NMN, NAD and NADP, nicotinamide pretreatment had minor effects on resistance to F. graminearum. Constitutive expression of the NMNAT gene, which encodes a rate-limiting enzyme for NAD biosynthesis, resulted in enhanced disease resistance in Arabidopsis. Thus, modifying the content of NAD-related metabolites can be used to optimize the defence signalling pathways activated in response to F. graminearum and facilitates the control of disease injury and mycotoxin accumulation in plants.
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