ArticleScientific reports2017
Virus and dsRNA-triggered transcriptional responses reveal key components of honey bee antiviral defense.
Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 63 papers, 1 of them a synthesis that pooled it.
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Who cites it
63 citing papers in PubMed, 1 synthesis or guideline pooled it, 114 citations in OpenAlex.
- Meta-analysis of honey bee neurogenomic response links Deformed wing virus type A to precocious behavioral maturation.Scientific reports · 2020Pooled it
- Virus specific impacts on honey bee flight performance are mediated by the octopamine pathway.bioRxiv : the preprint server for biology · 2026Article
- Homologs and Transcriptional Isoforms ofBiomolecules · 2026Article
- Quantitation of cytopathic honey bee viruses using the viral plaque assay method.The Journal of general virology · 2026Article
- Insight into the Prospects of RNA Interference for Honey Bee Pathogens and Parasite Control.Insects · 2026Review
- RNAi targeting ABCB1-like efflux transporters improves miticide efficacy in resistant Varroa mites.Parasites & vectors · 2026Article
- Metagenomic and gene expression patterns in declining commercial honey bee colonies.Scientific reports · 2026Article
- Contact Unmodified Antisense DNA Biotechnology (CUADb)-Based Oligonucleotide Insecticides and RNA Biocontrols: Molecular Bases and Potential in Plant Protection.Current issues in molecular biology · 2026Review
- Insect immune systems: same same but different but still same.Frontiers in immunology · 2026Review
- Neurotranscriptomic profiling of deformed wing virus-infected honey bee foragers (Apis mellifera) with different cognitive abilities.Biology open · 2025Article
- Inapparent virus infections differentially affect honey bee flight.Science advances · 2025Article
- Insights into miRNAs of the Stingless BeeNon-coding RNA · 2025Article
- Remodeling of Cellular Respiration and Insulin Signaling Are Part of a Shared Stress Response in Divergent Bee Species.Insects · 2025Article
- The intensity of the transcriptional response varies across infection with distinct viral strains in an insect host.BMC genomics · 2025Article
- Generational mutation patterns in a honey bee Deformed wing virus via infectious clones.PloS one · 2025Article
- Proteomics analysis of soluble secreted proteins ofFrontiers in cellular and infection microbiology · 2025Article
- Transcriptional dynamics during Heliothis zea nudivirus 1 infection in an ovarian cell line fromThe Journal of general virology · 2025Article
- DsRNA as pathogen-associated molecular pattern in innate immunity and multiple functions of the RNAi machinery complicate the use of RNAi in pest control.Frontiers in insect science · 2025Review
- Transcriptional control of a metabolic switch regulating cellular methylation reactions is part of a common response to stress in divergent bee species.The Journal of experimental biology · 2024Article
- Article
3 more citing papers are in PubMed but not listed here.
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3 authors at 1 institution in 1 country.
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Abstract
Recent high annual losses of honey bee colonies are associated with many factors, including RNA virus infections. Honey bee antiviral responses include RNA interference and immune pathway activation, but their relative roles in antiviral defense are not well understood. To better characterize the mechanism(s) of honey bee antiviral defense, bees were infected with a model virus in the presence or absence of dsRNA, a virus associated molecular pattern. Regardless of sequence specificity, dsRNA reduced virus abundance. We utilized next generation sequencing to examine transcriptional responses triggered by virus and dsRNA at three time-points post-infection. Hundreds of genes exhibited differential expression in response to co-treatment of dsRNA and virus. Virus-infected bees had greater expression of genes involved in RNAi, Toll, Imd, and JAK-STAT pathways, but the majority of differentially expressed genes are not well characterized. To confirm the virus limiting role of two genes, including the well-characterized gene, dicer, and a probable uncharacterized cyclin dependent kinase in honey bees, we utilized RNAi to reduce their expression in vivo and determined that virus abundance increased, supporting their involvement in antiviral defense. Together, these results further our understanding of honey bee antiviral defense, particularly the role of a non-sequence specific dsRNA-mediated antiviral pathway.
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