Evidence map›Paper›PMID 28743859›Full record

ArticleNature communications2017

Let-7 microRNA-dependent control of leukotriene signaling regulates the transition of hematopoietic niche in mice.

Xuan Jiang, John S Hawkins, Jerry Lee, Carlos O Lizama, Frank L Bos, Joan P Zape, Prajakta Ghatpande, Yongbo Peng, Justin Louie, Giorgio Lagna and 2 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature communications, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.1field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 13 citations in OpenAlex.

  1. Nutrient regulation of development and cell fate decisions.Development (Cambridge, England) · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 1 institution in 1 country.

Xuan JiangCardiovascular Research Institute, University of California, San Francisco, San Francisco, CA, 94143, USA.
John S HawkinsCardiovascular Research Institute, University of California, San Francisco, San Francisco, CA, 94143, USA.
Jerry LeeCardiovascular Research Institute, University of California, San Francisco, San Francisco, CA, 94143, USA.
Carlos O LizamaCardiovascular Research Institute, University of California, San Francisco, San Francisco, CA, 94143, USA.
Frank L BosCardiovascular Research Institute, University of California, San Francisco, San Francisco, CA, 94143, USA.
Joan P ZapeCardiovascular Research Institute, University of California, San Francisco, San Francisco, CA, 94143, USA.
Prajakta GhatpandeCardiovascular Research Institute, University of California, San Francisco, San Francisco, CA, 94143, USA.
Yongbo PengCardiovascular Research Institute, University of California, San Francisco, San Francisco, CA, 94143, USA.
Justin LouieCardiovascular Research Institute, University of California, San Francisco, San Francisco, CA, 94143, USA.
Giorgio LagnaCardiovascular Research Institute, University of California, San Francisco, San Francisco, CA, 94143, USA.
Ann C ZoveinCardiovascular Research Institute, University of California, San Francisco, San Francisco, CA, 94143, USA.ORCID http://orcid.org/0000-0003-3298-7308
Akiko HataCardiovascular Research Institute, University of California, San Francisco, San Francisco, CA, 94143, USA. akiko.hata@ucsf.edu.ORCID http://orcid.org/0000-0003-3784-1738
University of California, San Francisco · US

Funding

MOLECULAR AND CELLULAR BASIS OF CARDIOVASCULAR DISEASET32HL007731 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Brian L Black · 1992 to 2026
$12.4M
STRUCTURAL BIOLOGY TRAINING PROGRAMT32GM008284 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI KORTEMME, TANJA · 1988 to 2022
$10.1M
PREDOCTORAL TRAINING IN BIOMEDICAL SCIENCEST32GM008568 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI ANSEL, KARL MARK · 1995 to 2019
$6.3M
Engineering human endothelium for hematopoietic stem cell productionDP2HL117743 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI ZOVEIN, ANN CAPELA · 2012 to 2012
$2.4M
Role of miRNAs in Vascular PhysiologyR01HL093154 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI HATA, AKIKO · 2009 to 2012
$1.6M
Role of the PDGF signaling pathway in pulmonary artery hypertensionR01HL116191 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI HATA, AKIKO · 2013 to 2016
$1.5M
Mechanisms of TGFB Signal TransductionR01HL108317 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI HATA, AKIKO · 2011 to 2014
$1.5M
NHLBI NIH HHS DP2 HL117743NHLBI NIH HHS R01 HL093154NHLBI NIH HHS R01 HL108317NHLBI NIH HHS R01 HL116191NHLBI NIH HHS T32 HL007731NIGMS NIH HHS T32 GM008284NIGMS NIH HHS T32 GM008568Wellcome Trust
6 · The paper itself

Abstract

Hematopoietic stem and progenitor cells arise from the vascular endothelium of the dorsal aorta and subsequently switch niche to the fetal liver through unknown mechanisms. Here we report that vascular endothelium-specific deletion of mouse Drosha (Drosha

Indexed as

AnimalsAortaEndothelium, VascularHematopoiesisHematopoietic Stem CellsLeukotriene B4LiverMice, 129 StrainMice, Inbred C57BLMice, KnockoutMice, TransgenicMicroRNAsMicroscopy, FluorescenceReverse Transcriptase Polymerase Chain ReactionRibonuclease IIISignal TransductionDrosha protein, mouseLeukotriene B4MicroRNAsmirnlet7 microRNA, mouseRibonuclease III

Identifiers

PMID28743859
PMCPMC5527007
OpenAlexW2737963069

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.