Evidence map›Paper›PMID 28743822›Full record

Observational studyPhysiological reports2017

Bronchial microdialysis monitoring of inflammatory response in open abdominal aortic aneurysm repair; an observational study.

Stig S Tyvold, Torbjørn Dahl, Stein Dragsund, Sigurd Gunnes, Oddveig Lyng, Jan K Damås, Petter Aadahl, Erik Solligård

Registry-linked trialOpen access · goldAbstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Physiological reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01322295 (Human Bronchial Microdialysis in Open Aortic Aneurysm Repair), which is not on this map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.2field-weighted citation impact, top 43% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01322295 completednot on this map

Human Bronchial Microdialysis in Open Aortic Aneurysm Repair

TypeobservationalSponsorNorwegian University of Science and TechnologyRan2011 to 2011Enrolled16ConditionsAcute Lung Injury
3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Observational
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Stig S TyvoldDepartment of Circulation and Medical Imaging, Norwegian University of Science and Technology, Trondheim, Norway styvold@gmail.com.ORCID http://orcid.org/0000-0003-2697-7955
Torbjørn DahlDepartment of Circulation and Medical Imaging, Norwegian University of Science and Technology, Trondheim, Norway.
Stein DragsundClinic of Anesthesia and Intensive Care, St. Olavs Hospital, Trondheim, Norway.
Sigurd GunnesDepartment of Circulation and Medical Imaging, Norwegian University of Science and Technology, Trondheim, Norway.
Oddveig LyngFaculty of Medicine, Norwegian University of Science and Technology, Trondheim, Norway.
Jan K DamåsCentre of Molecular Inflammation Research, Department of Cancer Research and Molecular Medicine, Norwegian University of Science and Technology, Trondheim, Norway.
Petter AadahlDepartment of Circulation and Medical Imaging, Norwegian University of Science and Technology, Trondheim, Norway.
Erik SolligårdDepartment of Circulation and Medical Imaging, Norwegian University of Science and Technology, Trondheim, Norway.
Norwegian University of Science and Technology · NOSt Olav's University Hospital · NO

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Aortic surgery results in ischemia-reperfusion injury that induces an inflammatory response and frequent complications. The magnitude of the inflammatory response in blood and bronchi may be associated with the risk of immediate complications. The purpose of the study was to evaluate bronchial microdialysis as a continuous monitoring of cytokines in bronchial epithelial lining fluid (ELF) and to determine whether bronchial ELF cytokine levels reflect the ischemia-reperfusion injury and risk for complications during open abdominal aortic aneurysm (AAA) repair. We measured cytokines in venous blood using microdialysis and in serum for comparison. Sixteen patients scheduled for elective open AAA repair were included in a prospective observational study. Microdialysis catheters were introduced into a bronchi and a cubital vein. Eighteen cytokines were measured using a Bio-Plex Magnetic Human Cytokine Panel. Samples were collected before and during cross-clamping of the aorta as well as from 0 to 60 min and from 60 to 120 min of reperfusion. The ELF levels of several cytokines changed significantly during reperfusion. In particular, IL-6 increased more than 10-fold and IL-13 more than 5-fold during ischemia and reperfusion. Also, the venous levels of several inflammatory and anti-inflammatory cytokines increased and exhibited their highest concentration during reperfusion. Both bronchial and venous cytokine levels correlated with duration of the procedure, intensive care days, and preoperative kidney disease. Three patients suffered organ failure as a direct consequence of the procedure, and in these patients the bronchial ELF concentrations of 17 of 18 cytokines differed significantly from patients without such complications. Bronchial microdialysis is suited for continuous monitoring of inflammation during open AAA repair. The bronchial ELF cytokine levels may be useful in predicting immediate complications such as organ failure in patients undergoing vascular surgery.

Indexed as

AgedAged, 80 and overAortic Aneurysm, AbdominalBronchoalveolar Lavage FluidCytokinesFemaleHumansMaleMicrodialysisMiddle AgedMonitoring, IntraoperativePostoperative ComplicationsReperfusion InjuryCytokinesAortic surgerycytokineslungreperfusion injury

Identifiers

PMID28743822
PMCPMC5532484
OpenAlexW2737574945

What OpenQuestion holds

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LicenceCC BY
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.