Trial reportmBio2017
Penile Anaerobic Dysbiosis as a Risk Factor for HIV Infection.
Open access · goldAbstract readRandomized Controlled Trial
In one paragraph
Trial report in mBio, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 58 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
58citing papers in PubMed, 1 pooled it
8.4field-weighted citation impact, top 2% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
58 citing papers in PubMed, 1 synthesis or guideline pooled it, 82 citations in OpenAlex.
- Effects of Probiotics on Preterm Infant Gut Microbiota Across Populations: A Systematic Review and Meta-Analysis.Advances in nutrition (Bethesda, Md.) · 2024Pooled it
- Impact of antimicrobials on penile HIV susceptibility and immunology in uncircumcised men: A randomized phase 1/2 clinical trial.Cell reports. Medicine · 2024Trial
- HIV Transmission and Immunology of the Male Reproductive Tract.American journal of reproductive immunology (New York, N.Y. : 1989) · 2026Review
- The Gut-Vagina Axis.Microorganisms · 2026Review
- CD11c+ myeloid cells are the predominant CD4+CCR5+ immune population in the foreskin and are increased in men with HIV-associated penile anaerobes.bioRxiv : the preprint server for biology · 2026Article
- Anaerobe-Driven Inflammation and Epithelial Barrier Disruption in Genital HIV Acquisition.American journal of reproductive immunology (New York, N.Y. : 1989) · 2026Review
- Article
- HIV-1 interactions with sialic acid-binding bacterial lectins promote virus infectivityFrontiers in cellular and infection microbiology · 2026Article
- Real-time PCR assay design and validation for Prevotella bivia, Peptostreptococcus anaerobius, and Dialister micraerophilus, bacteria associated with increased HIV susceptibility.Scientific reports · 2025Article
- Uncertainty Modeling Outperforms Machine Learning for Microbiome Data Analysis.bioRxiv : the preprint server for biology · 2025Article
- Article
- Recent Advances in Our Understanding of Human Inflammatory Dendritic Cells in Human Immunodeficiency Virus Infection.Viruses · 2025Review
- Partial normalization of microbiota dysbiosis in condyloma acuminatum patients following treatment.Frontiers in cellular and infection microbiology · 2025Article
- Rectal mucosal inflammation, microbiome, and wound healing in men who have sex with men who engage in receptive anal intercourse.Scientific reports · 2024Article
- Integrated analysis of rectal mucosal microbiome and transcriptome reveals a distinct microenvironment among young MSM.JCI insight · 2024Article
- Insights into the assembly of the neovaginal microbiota in Mayer-Rokitansky-Küster-Hauser (MRKH) syndrome patients.Nature communications · 2024Article
- Comparison between a deep-learning and a pixel-based approach for the automated quantification of HIV target cells in foreskin tissue.Scientific reports · 2024Article
- Ecology meets reproductive medicine in HIV prevention: the case for geography-informed approaches for bacterial vaginosis in Africa.Frontiers in reproductive health · 2024Review
- Insertive vaginal sex is associated with altered penile immunology and enrichment of Gardnerella vaginalis in uncircumcised Ugandan men.American journal of reproductive immunology (New York, N.Y. : 1989) · 2024Article
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
13 authors at 6 institutions in 3 countries.
Cindy M LiuDepartment of Environmental and Occupational Health, Milken Institute School of Public Health, George Washington University, Washington, DC, USA cindyliu@gwu.edu.
Jessica L ProdgerNational Institute of Allergy and Infectious Diseases, National Institutes of Health, Baltimore, Maryland, USA.
Aaron A R TobianDepartment of Epidemiology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland, USA.
Alison G AbrahamDepartment of Epidemiology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland, USA.
Godfrey KigoziRakai Health Sciences Program, Entebbe, Uganda.
Bruce A HungateDepartment of Biological Sciences, Center for Ecosystem Science and Society, Northern Arizona University, Flagstaff, Arizona, USA.ORCID 0000-0002-7337-1887
Maliha AzizDepartment of Environmental and Occupational Health, Milken Institute School of Public Health, George Washington University, Washington, DC, USA.
Fred NalugodaRakai Health Sciences Program, Entebbe, Uganda.
Sanjeev SariyaCenter for Microbiomics and Human Health, Division of Pathogen Genomics, Translational Genomics Research Institute, Flagstaff, Arizona, USA.
David SerwaddaRakai Health Sciences Program, Entebbe, Uganda.
Rupert KaulDepartment of Medicine, University of Toronto, Toronto, Canada.
Ronald H GrayDepartment of Epidemiology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland, USA.
Lance B PriceDepartment of Environmental and Occupational Health, Milken Institute School of Public Health, George Washington University, Washington, DC, USA.
Translational Genomics Research Institute · USJohns Hopkins University · USRakai Health Sciences Program · UGNational Institutes of Health · USNorthern Arizona University · USUniversity of Toronto · CA
Funding
Male Circumcision Trial for HIV Prevention, Rakai-UgandaU01AI051171 · NIAID · JOHNS HOPKINS UNIVERSITY · PI GRAY, RONALD H · 2002 to 2006
$8.9MThe role of penile bacteria and inflammation in HIV susceptibility; Rakai, UgandaR01AI123002 · NIAID · GEORGE WASHINGTON UNIVERSITY · PI LIU, CINDY · 2016 to 2020
$3.3MGenital Anaerobes, Inflammation and HIV Risk; RakaiR01AI087409 · NIAID · JOHNS HOPKINS UNIVERSITY · PI GRAY, RONALD H, PRICE, LANCE BRADLEY · 2010 to 2012
$2.5MPenile Microbiome, Inflammation and HIV Susceptibility During Sexual Debut and Maturation Among Male AdolescentsR01AI128779 · NIAID · JOHNS HOPKINS UNIVERSITY · PI TOBIAN, AARON A · 2017 to 2020
$2.1MMale Circumcision and Use of Foreskin Tissues for HIV Prevention in UgandaD43TW009578 · FIC · JOHNS HOPKINS UNIVERSITY · PI GRAY, RONALD H · 2013 to 2017
$1.3MCIHR TMI-138656FIC NIH HHS D43 TW009578NIAID NIH HHS R01 AI087409NIAID NIH HHS R01 AI123002NIAID NIH HHS R01 AI128779NIAID NIH HHS U01 AI051171
Abstract
Sexual transmission of HIV requires exposure to the virus and infection of activated mucosal immune cells, specifically CD4
Indexed as
DysbiosisAdolescentAdultAnaerobiosisBacteria, AnaerobicCase-Control StudiesCircumcision, MaleFemaleForeskinHeterosexualityHIV InfectionsHIV SeropositivityHumansInterleukin-8MaleMicrobiotaCXCL8 protein, humanInterleukin-8anaerobescytokinesforeskin inflammationhuman immunodeficiency viruspenile microbiomesusceptibility
Identifiers
What OpenQuestion holds
Textmetadata
LicenceCC BY
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.