Evidence map›Paper›PMID 28743810›Full record

ArticlemBio2017

Polymyxin Combinations Combat

Zackery P Bulman, Liang Chen, Thomas J Walsh, Michael J Satlin, Yuli Qian, Jürgen B Bulitta, Charles A Peloquin, Patricia N Holden, Roger L Nation, Jian Li and 2 more

Open access · goldAbstract read
In one paragraph

Article in mBio, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
38citing papers in PubMed, 1 pooled it
2.3field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

38 citing papers in PubMed, 1 synthesis or guideline pooled it, 61 citations in OpenAlex.

  1. Guideline
  2. Article
  3. Review
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Global epidemiology, genetic environment, risk factors and therapeutic prospects ofFrontiers in cellular and infection microbiology · 2022
    Review
  10. Emergence of a Multidrug-ResistantInfection and drug resistance · 2022
    Article
  11. Article
  12. Article
  13. Article
  14. Review
  15. Article
  16. Comprehensive Genomic Investigation of Coevolution ofGlobal challenges (Hoboken, NJ) · 2021
    Article
  17. Article
  18. Article
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 5 institutions in 2 countries.

Zackery P BulmanLaboratory for Antimicrobial Dynamics, NYS Center of Excellence in Bioinformatics and Life Sciences, Buffalo, New York, USA.
Liang ChenPublic Health Research Institute, New Jersey Medical School, Rutgers, the State University of New Jersey, Newark, New Jersey, USA.
Thomas J WalshWeill Cornell Medical College, Cornell University, New York, New York, USA.
Michael J SatlinWeill Cornell Medical College, Cornell University, New York, New York, USA.
Yuli QianCenter for Pharmacometrics and Systems Pharmacology, Department of Pharmaceutics, College of Pharmacy, University of Florida, Orlando, Florida, USA.
Jürgen B BulittaCenter for Pharmacometrics and Systems Pharmacology, Department of Pharmaceutics, College of Pharmacy, University of Florida, Orlando, Florida, USA.
Charles A PeloquinDepartment of Pharmacotherapy and Translational Research, University of Florida, College of Pharmacy, Gainesville, Florida, USA.
Patricia N HoldenLaboratory for Antimicrobial Dynamics, NYS Center of Excellence in Bioinformatics and Life Sciences, Buffalo, New York, USA.
Roger L NationDrug Delivery, Disposition and Dynamics, Monash Institute of Pharmaceutical Sciences, Monash University, Melbourne, Australia.
Jian LiDrug Delivery, Disposition and Dynamics, Monash Institute of Pharmaceutical Sciences, Monash University, Melbourne, Australia.
Barry N KreiswirthPublic Health Research Institute, New Jersey Medical School, Rutgers, the State University of New Jersey, Newark, New Jersey, USA kreiswba@njms.rutgers.edu btsuji@buffalo.edu.
Brian T TsujiLaboratory for Antimicrobial Dynamics, NYS Center of Excellence in Bioinformatics and Life Sciences, Buffalo, New York, USA kreiswba@njms.rutgers.edu btsuji@buffalo.edu.
University at Buffalo, State University of New York · USUniversity of Florida · USCornell University · USMonash University · AURutgers, The State University of New Jersey · US

Funding

The molecular basis of the epidemic blaKPC gene KlebsiellaR01AI090155 · NIAID · UNIV OF MED/DENT OF NJ-NJ MEDICAL SCHOOL · PI KREISWIRTH, BARRY NEAL · 2011 to 2021
$7.2M
Novel PK/PD Strategies for Polymyxin Combinations against Gram-negative SuperbugsR01AI111990 · NIAID · STATE UNIVERSITY OF NEW YORK AT BUFFALO · PI LI, JIAN, TSUJI, BRIAN · 2014 to 2018
$4.4M
NIAID NIH HHS R01 AI090155NIAID NIH HHS R01 AI111990
6 · The paper itself

Abstract

The rapid increase of carbapenem resistance in Gram-negative bacteria has resurrected the importance of the polymyxin antibiotics. The recent discovery of plasmid-mediated polymyxin resistance (

Indexed as

Anti-Bacterial Agentsbeta-LactamasesCarbapenemsColistinDrug CombinationsDrug Resistance, Multiple, BacterialEscherichia coliEscherichia coli ProteinsHumansMicrobial Sensitivity TestsModels, BiologicalPlasmidsPolymyxin BPolymyxinsAnti-Bacterial Agentsbeta lactamase NDM-5, E colibeta-LactamasesCarbapenemsColistinDrug CombinationsEscherichia coli ProteinsMCR-1 protein, E coliPolymyxin BPolymyxinsamikacinaztreonamcarbapenem-resistantEnterobacteriaceaeMCR-1NDM-5polymyxins

Identifiers

PMID28743810
PMCPMC5527306
OpenAlexW2739333629

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.