Evidence map›Paper›PMID 28743741›Full record

ArticleThe Journal of biological chemistry2017

CDK9 and SPT5 proteins are specifically required for expression of herpes simplex virus 1 replication-dependent late genes.

Zhiyuan Zhao, Ka-Wei Tang, Isabella Muylaert, Tore Samuelsson, Per Elias

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of biological chemistry, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
0.9field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 16 citations in OpenAlex.

  1. Trial
  2. Article
  3. The Antiviral Activity of Polyphenols.Molecular nutrition & food research · 2025
    Review
  4. Review
  5. Article
  6. Article
  7. Article
  8. Review
  9. Article
  10. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Zhiyuan ZhaoFrom the Institute of Biomedicine, Department of Medical Biochemistry and Cell Biology, Sahlgrenska Academy, University of Gothenburg, Box 440, SE-405 30 Gothenburg, Sweden.
Ka-Wei TangFrom the Institute of Biomedicine, Department of Medical Biochemistry and Cell Biology, Sahlgrenska Academy, University of Gothenburg, Box 440, SE-405 30 Gothenburg, Sweden.
Isabella MuylaertFrom the Institute of Biomedicine, Department of Medical Biochemistry and Cell Biology, Sahlgrenska Academy, University of Gothenburg, Box 440, SE-405 30 Gothenburg, Sweden.
Tore SamuelssonFrom the Institute of Biomedicine, Department of Medical Biochemistry and Cell Biology, Sahlgrenska Academy, University of Gothenburg, Box 440, SE-405 30 Gothenburg, Sweden.
Per EliasFrom the Institute of Biomedicine, Department of Medical Biochemistry and Cell Biology, Sahlgrenska Academy, University of Gothenburg, Box 440, SE-405 30 Gothenburg, Sweden per.elias@medkem.gu.se.
University of Gothenburg · SE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

DNA replication greatly enhances expression of the herpes simplex virus 1 (HSV-1) γ2 late genes by still unknown mechanisms. Here, we demonstrate that 5,6-dichloro-1-β-d-ribofuranosylbenzimidazole (DRB), an inhibitor of CDK9, suppresses expression of γ2 late genes with an IC

Indexed as

DNA ReplicationGene Expression Regulation, ViralVirus ReplicationAmino Acid SubstitutionAntiviral AgentsCell LineChromatin ImmunoprecipitationChromosomal Proteins, Non-HistoneComputational BiologyCyclin-Dependent Kinase 9DichlororibofuranosylbenzimidazoleHerpesvirus 1, HumanHumansImmediate-Early ProteinsImmunoprecipitationMutationAntiviral AgentsChromosomal Proteins, Non-HistoneCyclin-Dependent Kinase 9DichlororibofuranosylbenzimidazoleICP27 protein, human herpesvirus 1Immediate-Early Proteinsnegative elongation factorNucleic Acid Synthesis InhibitorsProtein Kinase InhibitorsSPT5 transcriptional elongation factorTranscriptional Elongation FactorsTranscription FactorsViral Proteinscyclin-dependent kinase (CDK)gene expressionherpesviruspost-transcriptional regulationviral replication

Identifiers

PMID28743741
PMCPMC5602406
OpenAlexW2738687461

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.