Evidence map›Paper›PMID 28743729›Full record

ArticleJournal of lipid research2017

Obesity is associated with an altered HDL subspecies profile among adolescents with metabolic disease.

W Sean Davidson, Anna Heink, Hannah Sexmith, Lawrence M Dolan, Scott M Gordon, James D Otvos, John T Melchior, Deborah A Elder, Jane Khoury, Esmond Geh and 1 more

Abstract read
In one paragraph

Article in Journal of lipid research, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed.

  1. Trial
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  5. Article
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  7. Article
  8. High LDL Particle and APOB Concentrations in Patients With Adrenal Cortical Adenomas.The Journal of clinical endocrinology and metabolism · 2024
    Article
  9. Article
  10. Review
  11. Article
  12. Review
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  15. Article
  16. Article
  17. Article
  18. Article
  19. Review
  20. Obesity-Related Changes in High-Density Lipoprotein Metabolism and Function.International journal of molecular sciences · 2020
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

W Sean DavidsonCenter for Lipid and Arteriosclerosis Science, Department of Pathology and Laboratory Medicine, University of Cincinnati, Cincinnati, OH 45237-0507.
Anna HeinkDepartment of Pediatrics, Cincinnati Childrenʼns Hospital Research Foundation, Cincinnati, OH 45229-3039.
Hannah SexmithDepartment of Pediatrics, Cincinnati Childrenʼns Hospital Research Foundation, Cincinnati, OH 45229-3039.
Lawrence M DolanDepartment of Pediatrics, Cincinnati Childrenʼns Hospital Research Foundation, Cincinnati, OH 45229-3039.
Scott M GordonLipoprotein Metabolism Section, National Heart, Lung, and Blood Institute, Bethesda, MD 20892.
James D OtvosLaboratory Corporation of America® Holdings, Morrisville, NC 27560.
John T MelchiorCenter for Lipid and Arteriosclerosis Science, Department of Pathology and Laboratory Medicine, University of Cincinnati, Cincinnati, OH 45237-0507.
Deborah A ElderDepartment of Pediatrics, Cincinnati Childrenʼns Hospital Research Foundation, Cincinnati, OH 45229-3039.
Jane KhouryDepartment of Pediatrics, Cincinnati Childrenʼns Hospital Research Foundation, Cincinnati, OH 45229-3039.
Esmond GehDepartment of Pediatrics, Cincinnati Childrenʼns Hospital Research Foundation, Cincinnati, OH 45229-3039.
Amy S ShahDepartment of Pediatrics, Cincinnati Childrenʼns Hospital Research Foundation, Cincinnati, OH 45229-3039. Electronic address: amy.shah@cchmc.org.

Funding

Cincinnati Center for Clinical and Translational Sciences and TrainingUL1TR000077 · NCATS · UNIVERSITY OF CINCINNATI · PI HEUBI, JAMES E., TSEVAT, JOEL · 2012 to 2014
$9.9M
LANDMARKS IN THE PROGRESSION TO TYPE II DIABETESR01DK059183 · NIDDK · CHILDREN'S HOSPITAL MED CTR (CINCINNATI) · PI DOLAN, LAWRENCE M · 2000 to 2004
$4.5M
Apolipoprotein A-I structure in high density lipoproteinsR01HL067093 · NHLBI · UNIVERSITY OF CINCINNATI · PI DAVIDSON, W SEAN · 2002 to 2016
$4.3M
Understanding the Role of HDL Subspecies in Adolescents with Type 2 DiabetesK23HL118132 · NHLBI · CINCINNATI CHILDRENS HOSP MED CTR · PI SHAH, AMY SANGHAVI · 2014 to 2018
$855k
The molecular basis for high density lipoprotein heterogeneityR21HL104136 · NHLBI · UNIVERSITY OF CINCINNATI · PI DAVIDSON, W SEAN · 2010 to 2011
$440k
NCATS NIH HHS UL1 TR000077NHLBI NIH HHS K23 HL118132NHLBI NIH HHS R01 HL067093NHLBI NIH HHS R21 HL104136NIDDK NIH HHS R01 DK059183
6 · The paper itself

Abstract

We aimed to determine the risk factors associated with the depletion of large HDL particles and enrichment of small HDL particles observed in adolescents with T2D. Four groups of adolescents were recruited:

Indexed as

AdolescentFemaleGlucoseHumansInsulin ResistanceLipoproteins, HDLMaleMetabolic DiseasesObesityYoung AdultGlucoseLipoproteins, HDLdiabeteshigh density lipoproteininsulin resistancephospholipids

Identifiers

PMID28743729
PMCPMC5580903

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.