ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2017
Changes in White Matter Microstructure Impact Cognition by Disrupting the Ability of Neural Assemblies to Synchronize.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers, 2 of them syntheses that pooled it.
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Who cites it
35 citing papers in PubMed, 2 syntheses or guidelines pooled it.
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- Cognitive Function in Pediatric Hypoplastic Left Heart Syndrome: Systematic Review and Meta-Analysis.Journal of pediatric psychology · 2019Pooled it
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- Loss of regional theta differentiation in TMS-EEG response marks network dysfunction in psychosis risk.Translational psychiatry · 2026Article
- The role of white matter myelin in structural-functional network coupling.Communications biology · 2026Article
- A computational roadmap to activity-dependent myelination.Frontiers in computational neuroscience · 2026Article
- Path integration impairments reveal early cognitive changes in subjective cognitive decline.Science advances · 2025Article
- Path integration impairments reveal early cognitive changes in Subjective Cognitive Decline.bioRxiv : the preprint server for biology · 2025Article
- Tumor-infiltrating nerves: unraveling the role of cancer neuroscience in tumorigenesis, disease progression, and emerging therapies.Discover oncology · 2025Review
- Estimating Chronological Age From the Electrical Activity of the Brain: How EEG-Age Can Be Used as a Marker of General Brain Functioning.Psychophysiology · 2025Article
- Visual system structural and functional connections during face viewing in body dysmorphic disorder.bioRxiv : the preprint server for biology · 2024Article
- Cerebral white matter myelination is associated with longitudinal changes in processing speed across the adult lifespan.Brain communications · 2024Article
- Compensatory mechanisms amidst demyelinating disorders: insights into cognitive preservation.Brain communications · 2024Article
- Review
- The alterations of spontaneous neural activities and white matter microstructures in anti-N-methyl-D-aspartate receptor encephalitis: a resting-state fMRI and DTI study.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2023Article
- Intra-amniotic inflammation in the mid-trimester of pregnancy is a risk factor for neuropsychological disorders in childhood.Journal of perinatal medicine · 2023Article
- White matter changes underlie hypertension-related cognitive decline in older adults.NeuroImage. Clinical · 2023Review
- The human brain connectome weighted by the myelin content and total intra-axonal cross-sectional area of white matter tracts.Network neuroscience (Cambridge, Mass.) · 2023Article
- Biophysical mechanism underlying compensatory preservation of neural synchrony over the adult lifespan.Communications biology · 2022Article
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8 authors.
Funding
Abstract
Cognition is compromised by white matter (WM) injury but the neurophysiological alterations linking them remain unclear. We hypothesized that reduced neural synchronization caused by disruption of neural signal propagation is involved. To test this, we evaluated group differences in: diffusion tensor WM microstructure measures within the optic radiations, primary visual area (V1), and cuneus; neural phase synchrony to a visual attention cue during visual-motor task; and reaction time to a response cue during the same task between 26 pediatric patients (17/9: male/female) treated with cranial radiation treatment for a brain tumor (12.67 ± 2.76 years), and 26 healthy children (16/10: male/female; 12.01 ± 3.9 years). We corroborated our findings using a corticocortical computational model representing perturbed signal conduction from myelin. Patients show delayed reaction time, WM compromise, and reduced phase synchrony during visual attention compared with healthy children. Notably, using partial least-squares-path modeling we found that WM insult within the optic radiations, V1, and cuneus is a strong predictor of the slower reaction times via disruption of neural synchrony in visual cortex. Observed changes in synchronization were reproduced in a computational model of WM injury. These findings provide new evidence linking cognition with WM via the reliance of neural synchronization on propagation of neural signals.
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