Evidence map›Paper›PMID 28743702›Full record

ArticleAntimicrobial agents and chemotherapy2017

Progressive Dispersion of Azole Resistance in Aspergillus fumigatus: Fatal Invasive Aspergillosis in a Patient with Acute Myeloid Leukemia Infected with an A. fumigatus Strain with a

Susann Rößler, Oliver Bader, Friedrich Stölzel, Ulrich Sommer, Birgit Spiess, Stephan Geibel, Dieter Buchheidt, Uwe Groß, Gustavo Baretton, Enno Jacobs and 1 more

Abstract readCase Reports
In one paragraph

Article in Antimicrobial agents and chemotherapy, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Susann RößlerInstitute of Medical Microbiology and Hygiene, Technische Universität Dresden, Dresden, Germany susann.roessler@tu-dresden.de Luis.Ostrosky-Zeichner@uth.tmc.edu.
Oliver BaderInstitute for Medical Microbiology, University Medical Center Göttingen, Göttingen, Germany.ORCID 0000-0002-1534-440X
Friedrich StölzelDepartment of Internal Medicine I, University Hospital Carl Gustav at the Technische Universität Dresden, Dresden, Germany.
Ulrich SommerDepartment of Pathology, University Hospital Carl Gustav at the Technische Universität Dresden, Dresden, Germany.
Birgit SpiessThird Department of Internal Medicine, Hematology and Oncology, Mannheim University Hospital, University of Heidelberg, Mannheim, Germany.
Stephan GeibelInstitute for Medical Microbiology, University Medical Center Göttingen, Göttingen, Germany.
Dieter BuchheidtThird Department of Internal Medicine, Hematology and Oncology, Mannheim University Hospital, University of Heidelberg, Mannheim, Germany.
Uwe GroßInstitute for Medical Microbiology, University Medical Center Göttingen, Göttingen, Germany.
Gustavo BarettonDepartment of Pathology, University Hospital Carl Gustav at the Technische Universität Dresden, Dresden, Germany.
Enno JacobsInstitute of Medical Microbiology and Hygiene, Technische Universität Dresden, Dresden, Germany.
Luis Ostrosky-ZeichnerLaboratory of Mycology Research, Center for Antimicrobial Resistance and Microbial Genomics, McGovern Medical School, Houston, Texas, USA susann.roessler@tu-dresden.de Luis.Ostrosky-Zeichner@uth.tmc.edu.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Patients with hematologic malignancies as well as allogeneic hematopoietic stem cell transplantation (HSCT) patients are at high risk for invasive aspergillosis. Here, we report a culture- and autopsy-proven fatal invasive aspergillosis in an allogeneic HSTC patient which he developed despite posaconazole prophylaxis. The agent was determined to be an azole-resistant

Indexed as

AgedAllelesAmphotericin BAntifungal AgentsAspergillus fumigatusAzolesCaspofunginCytochrome P-450 Enzyme SystemDrug Resistance, Multiple, FungalEchinocandinsFungal ProteinsHumansInvasive Pulmonary AspergillosisLeukemia, Myeloid, AcuteLipopeptidesMaleAmphotericin BAntifungal AgentsAzolesCaspofungincytochrome P-450 CYP51A, AspergillusCytochrome P-450 Enzyme SystemEchinocandinsFungal ProteinsLipopeptidesliposomal amphotericin BposaconazoleTriazolesVoriconazoleAspergillus fumigatusazole resistancebreakthrough aspergillosiscyp51A mutationhematopoietic stem cell transplantationinvasive aspergillosis

Identifiers

PMID28743702
PMCPMC5527573

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.