ArticleDevelopmental cell2017
Patterned Disordered Cell Motion Ensures Vertebral Column Symmetry.
Article in Developmental cell, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed.
- Tbx16 and mesogenin 1 promote presomitic mesoderm differentiation by repressing the mesodermal progenitor cell state.PLoS genetics · 2026Article
- A cadherin-integrin-ECM code for presomitic mesoderm fluidity.Development (Cambridge, England) · 2025Article
- Cdh2, a downstream target of Hes7, regulates somitogenesis by supporting FGF signalling.Development (Cambridge, England) · 2025Article
- Review
- The physical roles of different posterior tissues in zebrafish axis elongation.Nature communications · 2025Article
- Differential proliferation regulates multi-tissue morphogenesis during embryonic axial extension: integrating viscous modeling and experimental approaches.Development (Cambridge, England) · 2024Article
- An emerging role for tissue plasticity in developmental precision.Biochemical Society transactions · 2024Review
- Automated time-lapse data segmentation reveals in vivo cell state dynamics.Science advances · 2023Article
- Article
- Generation, Transmission, and Regulation of Mechanical Forces in Embryonic Morphogenesis.Small (Weinheim an der Bergstrasse, Germany) · 2022Review
- Are cell jamming and unjamming essential in tissue development?Cells & development · 2021Review
- Cell-to-cell heterogeneity in Sox2 and Bra expression guides progenitor motility and destiny.eLife · 2021Article
- Mechanical control of tissue shape and morphogenetic flows during vertebrate body axis elongation.Scientific reports · 2021Article
- Mechanical Coupling Coordinates the Co-elongation of Axial and Paraxial Tissues in Avian Embryos.Developmental cell · 2020Article
- Mechanics as a Means of Information Propagation in Development.BioEssays : news and reviews in molecular, cellular and developmental biology · 2020Article
- Anteroposterior Wnt-RA Gradient Defines Adhesion and Migration Properties of Neural Progenitors in Developing Spinal Cord.Stem cell reports · 2020Article
- Mechanics of Anteroposterior Axis Formation in Vertebrates.Annual review of cell and developmental biology · 2019Review
- Article
- Making and breaking symmetry in development, growth and disease.Development (Cambridge, England) · 2019Review
- Organization of Embryonic Morphogenesis via Mechanical Information.Developmental cell · 2019Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
The biomechanics of posterior embryonic growth must be dynamically regulated to ensure bilateral symmetry of the spinal column. Throughout vertebrate trunk elongation, motile mesodermal progenitors undergo an order-to-disorder transition via an epithelial-to-mesenchymal transition and sort symmetrically into the left and right paraxial mesoderm. We combine theoretical modeling of cell migration in a tail-bud-like geometry with experimental data analysis to assess the importance of ordered and disordered cell motion. We find that increasing order in cell motion causes a phase transition from symmetric to asymmetric body elongation. In silico and in vivo, overly ordered cell motion converts normal anisotropic fluxes into stable vortices near the posterior tail bud, contributing to asymmetric cell sorting. Thus, disorder is a physical mechanism that ensures the bilateral symmetry of the spinal column. These physical properties of the tissue connect across scales such that patterned disorder at the cellular level leads to the emergence of organism-level order.
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Registered trials
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