ArticleDevelopmental cell2017
GCL and CUL3 Control the Switch between Cell Lineages by Mediating Localized Degradation of an RTK.
Article in Developmental cell, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
32 citing papers in PubMed, 52 citations in OpenAlex.
- GCL pruning of PIP3 establishes the soma-germline boundary.The Journal of cell biology · 2026Article
- Harnessing the Power ofCold Spring Harbor perspectives in biology · 2026Review
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- A live-cell biosensor of in vivo receptor tyrosine kinase activity reveals feedback regulation of a developmental gradient.Cell reports · 2025Article
- Caspar modulates primordial germ cell fate both in an Oskar-dependent and Oskar-independent manner.Biology open · 2025Article
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- Review
- Article
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- Genome-Wide Identification and Expression Analysis of theInternational journal of molecular sciences · 2024Article
- Regulation of early spermatogenesis in the giant prawn Macrobrachium rosenbergii by a GCL homolog†.Biology of reproduction · 2024Article
- Smaug regulates germ plasm assembly and primordial germ cell number in Drosophila embryos.Science advances · 2024Article
- Finishing the egg.Genetics · 2024Article
- Proteins rather than mRNAs regulate nucleation and persistence of Oskar germ granules in Drosophila.Cell reports · 2023Article
- Germline/soma distinction ineLife · 2023Article
- Preformation and epigenesis converge to specify primordial germ cell fate in the early Drosophila embryo.PLoS genetics · 2022Article
- Profile of Ruth Lehmann.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Novel synthetic biology approaches for developmental systems.Stem cell reports · 2021Review
- Antagonism betweeneLife · 2021Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
The separation of germline from somatic lineages is fundamental to reproduction and species preservation. Here, we show that Drosophila Germ cell-less (GCL) is a critical component in this process by acting as a switch that turns off a somatic lineage pathway. GCL, a conserved BTB (Broad-complex, Tramtrack, and Bric-a-brac) protein, is a substrate-specific adaptor for Cullin3-RING ubiquitin ligase complex (CRL3
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.