Evidence map›Paper›PMID 28742855›Full record

ArticlePloS one2017

Decreases in heart rate variability are associated with postoperative complications in hip fracture patients.

Gernot Ernst, Leiv Otto Watne, Frede Frihagen, Torgeir Bruun Wyller, Andreas Dominik, Morten Rostrup

Registry-linked trialAbstract read
In one paragraph

Article in PloS one, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07783464 (Predictive Value of Early Postoperative Heart Rate Variability Changes From Baseline for Postoperative Delirium in Older Adults Undergoing Major Abdominal Surgery), which is not on this map. Cited by 20 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07783464 not yet recruitingnot on this mapstarted 2026, after this paper: background citation

Predictive Value of Early Postoperative Heart Rate Variability Changes From Baseline for Postoperative Delirium in Older Adults Undergoing Major Abdominal Surgery: A Prospective Cohort Study

TypeobservationalSponsorThe First Affiliated Hospital with Nanjing Medical UniversityRan2026 to 2027Enrolled500ConditionsPostoperative Delirium (POD), Heart Rate Variability (HRV)ArmsPerioperative Heart Rate Variability Changes
3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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  5. Time-course of heart rate variability after total hip arthroplasty.Journal of clinical monitoring and computing · 2024
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  16. Prognostic factors of in-hospital complications after hip fracture surgery: a scoping review.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2019
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Gernot ErnstDepartment of Anaesthesiology, Kongsberg hospital, Kongsberg, Norway.ORCID http://orcid.org/0000-0001-5224-0338
Leiv Otto WatneInstitute of Clinical Medicine, University of Oslo, Oslo, Norway.
Frede FrihagenInstitute of Clinical Medicine, University of Oslo, Oslo, Norway.
Torgeir Bruun WyllerInstitute of Clinical Medicine, University of Oslo, Oslo, Norway.
Andreas DominikTHM University of Applied Sciences, KITE, Giessen, Germany.
Morten RostrupSection of Cardiovascular and Renal Research, Oslo University Hospital, Oslo, Norway.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundTo explore relevant associations between deviations in linear and nonlinear heart rate variability (HRV) scores, and short-term morbidity and mortality in patients undergoing hip-surgery after a fracture.

methods165 patients with hip fractures being admitted for surgery at two hospitals were included in a prospective cohort study. A short-term ECG was recorded within 24 hours of arrival. 15 patients had to be excluded due to insufficient quality of the ECG recordings. 150 patients were included in the final analysis. Linear parameters were calculated in time domain: standard deviation of NN intervals (SDNN), root mean square of successive differences (rMSSD); and frequency domain: Total Power (TP), High Frequency Power (HF), Low Frequency Power (LF), Very Low Frequency Power (VLF), and the ratio of LF/HF. Postoperative outcome was evaluated at the time of discharge. This included occurrence of pneumonia, overall infection rate, stroke, myocardial infarction, and all-cause mortality.

resultsPatients experiencing complications had significantly lower rMSSD (p = 0.04), and TP (p = 0.03) preoperatively. Postoperative infections were predicted by decreased VLF preoperatively (p = 0.04). There was a significant association between pneumonia and LF/HF<1 (p = 0.03). The likelihood ratio to develop pneumonia when LF/HF < 1 was 6,1.

conclusionHRV seems to reflect the general frailty of the patient with hip fracture and might be used to identify patients in need of increased surveillance or prophylactic treatment.

Indexed as

Heart RateAgedAged, 80 and overFemaleHip FracturesHumansMalePneumoniaPostoperative ComplicationsProspective StudiesTreatment OutcomeUrinary Tract Infections

Identifiers

PMID28742855
PMCPMC5526500

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.